Mechanisms of Antiulcer Effect of an Active Ingredient Group of Modified Xiao Chaihu Decoction
Joint Authors
You, Pengtao
Liu, Wei
Yang, Mengling
Chen, Xuejian
Li, Li
Zhou, Aijun
Chen, Shuhe
Liu, Yanwen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study aimed to investigate the antiulcer activities and mechanisms of action of an active ingredient group (AIG) of Modified Xiao Chaihu Decoction (MXCD).
The gastroprotective action of the AIG was studied in ethanol-induced, pylorus ligature-induced, and acetic acid-induced in vivo gastric ulcer models.
The enzyme-linked immunoadsorbent assay (tumor necrosis factor-α (TNF-α), prostaglandin E2 (PGE2), and epidermal growth factor (EGF)), nitrate reductase assay (nitric oxide (NO)), western blot analysis (Bax, Bcl-2, cleaved-caspase-3, and cleaved-PARP (poly (ADP-Ribose) polymerase)), histological analysis (HE), and immunohistochemical analysis (HSP-70, p-AKT, and PCNA) were used to evaluate the anti-inflammatory, antiapoptotic, and healing properties of AIG.
Numerous mechanisms are involved in the antiulcer activity of AIG, including the increase of PGE2, NO, and EGF content and a reduction in TNF-α levels.
The upregulation of HSP-70, p-AKT, and PCNA seems to be directly linked to the healing effect of AIG.
Bax, Bcl-2, cleaved-caspase-3, and cleaved-PARP also play a key role in this process.
The AIG exerted gastroprotective effects by reducing antisecretory, anti-inflammatory, and antiapoptotic mechanisms.
In addition, it promotes cell proliferation.
Therefore, activation of the PI3K/AKT signaling pathway may play an important role in cell proliferation.
American Psychological Association (APA)
Liu, Wei& Yang, Mengling& Chen, Xuejian& Li, Li& Zhou, Aijun& Chen, Shuhe…[et al.]. 2018. Mechanisms of Antiulcer Effect of an Active Ingredient Group of Modified Xiao Chaihu Decoction. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155547
Modern Language Association (MLA)
Liu, Wei…[et al.]. Mechanisms of Antiulcer Effect of an Active Ingredient Group of Modified Xiao Chaihu Decoction. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155547
American Medical Association (AMA)
Liu, Wei& Yang, Mengling& Chen, Xuejian& Li, Li& Zhou, Aijun& Chen, Shuhe…[et al.]. Mechanisms of Antiulcer Effect of an Active Ingredient Group of Modified Xiao Chaihu Decoction. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155547