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Serrated Lesions of the Colon-Rectum: A Focus on New Diagnostic Tools and Current Management
Joint Authors
De Palma, Giovanni Domenico
Cassese, Gianluca
Amendola, Alfonso
Maione, Francesco
Giglio, Mariano Cesare
Pagano, Gianluca
Milone, Marco
Aprea, Giovanni
Luglio, Gaetano
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Prompt diagnosis and correct management of the so called “serrated lesions” (SLs) of the colon-rectum are generally considered of crucial importance in the past years, mainly due to their histological heterogeneity and peculiar clinical and molecular patterns; sometimes, they are missed at conventional endoscopy and are possibly implicated in the genesis of interval cancers.
The aim of this review is to focus on the diagnostic challenges of serrated lesions, underlying the role of both conventional endoscopy and novel technologies.
We will show how an accurate and precise diagnosis should immediately prompt the most appropriate therapy other than defining a proper follow-up program.
It will be emphasized how novel endoscopic techniques may provide better visualization of mucosal microsurface structures other than enhancing the microvascular architecture, in order to better define and characterize specific patterns of mucosal lesions of the gastrointestinal tract.
Standard therapy of SLs of the colon-rectum is still very debated, also due to the relatively lack of studies focusing on treatment issues.
The high risk of incomplete resection, together with the high rate of postcolonoscopy interval cancers, suggests the need of an extra care when facing this kind of lesions.
Given this background, we will outline useful technical tips and tricks in the resection of SLs, taking aspects such as the size and location of the lesions, as well as novel available techniques and technologies, other than future perspectives, including confocal laser endomicroscopy into consideration.
Follow-up of SLs is another hot topic, also considering that their clinical impact has been misunderstood for a long time.
The incidence of the so called interval colorectal cancer underlines how some weaknesses exist in current screening and follow-up programs.
Considering the lack of wide consensus for the management of some SLs, we will try to summarize and clarify the best strategies for their optimal management.
American Psychological Association (APA)
Cassese, Gianluca& Amendola, Alfonso& Maione, Francesco& Giglio, Mariano Cesare& Pagano, Gianluca& Milone, Marco…[et al.]. 2019. Serrated Lesions of the Colon-Rectum: A Focus on New Diagnostic Tools and Current Management. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1155553
Modern Language Association (MLA)
Cassese, Gianluca…[et al.]. Serrated Lesions of the Colon-Rectum: A Focus on New Diagnostic Tools and Current Management. Gastroenterology Research and Practice No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1155553
American Medical Association (AMA)
Cassese, Gianluca& Amendola, Alfonso& Maione, Francesco& Giglio, Mariano Cesare& Pagano, Gianluca& Milone, Marco…[et al.]. Serrated Lesions of the Colon-Rectum: A Focus on New Diagnostic Tools and Current Management. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1155553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155553