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Antifungal Activity of the Essential Oil of Echinops kebericho Mesfin: An In Vitro Study
Joint Authors
Beressa, Tamirat Bekele
Deyno, Serawit
Alele, Paul E.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Echinops kebericho is an endemic medicinal plant in Ethiopia widely used in the treatment of infectious and noninfectious diseases.
Essential oils are known for their antibacterial, antifungal, antiviral, insecticidal, and antioxidant properties.
This study evaluated the antifungal activity of essential oil from E.
kebericho against four common pathogenic fungi and two standard strains.
Methods.
The essential oil was obtained by hydrodistillation.
The antifungal screening was done by agar well diffusion method.
Minimal inhibitory concentrations (MICs) were determined by broth microdilution.
Minimal fungicidal concentrations (MFCs) were determined by subculturing fungal strains with no visible growth onto a Sabouraud dextrose agar (SDA) plate.
Results.
Candida albicans and Cryptococcus neoformans were highly sensitive while Aspergillus flavus did not show sensitivity up to 1 mg/ml of essential oil; MICs ranged from 0.083 mg/ml to 0.208 mg/ml.
Concentration and fungal species showed significant dose-dependent associations (p<0.0001) with antifungal activity.
The MICs of essential oil were comparable to those of the standard drug (fluconazole) against C.
glabrata and C.
krusei.
The lowest MFC of the essential oil was observed against Candida parapsilosis (0.145 mg/ml) while the highest MFC was against Candida krusei (0.667 mg/ml).
Conclusion.
Echinops kebericho essential oil showed noteworthy antifungal activity against Cryptococcus neoformans, Candida albicans, and Candida glabrata and could be a potential candidate for further antifungal drug development.
American Psychological Association (APA)
Beressa, Tamirat Bekele& Deyno, Serawit& Alele, Paul E.. 2020. Antifungal Activity of the Essential Oil of Echinops kebericho Mesfin: An In Vitro Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155560
Modern Language Association (MLA)
Beressa, Tamirat Bekele…[et al.]. Antifungal Activity of the Essential Oil of Echinops kebericho Mesfin: An In Vitro Study. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1155560
American Medical Association (AMA)
Beressa, Tamirat Bekele& Deyno, Serawit& Alele, Paul E.. Antifungal Activity of the Essential Oil of Echinops kebericho Mesfin: An In Vitro Study. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155560