Traditional Chinese Medicine Formulation Huangqi Jianzhong Tang Improves Cardiac Function after Myocardial Infarction in Rats
Joint Authors
Zhang, Guo-Xing
Yu, Jia-Yu
Bao, Ya-Ru
Jiang, Wen-Yi
Chen, Jing-Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Huangqi Jianzhong Tang (HQJZT) is a traditional Chinese herbal formula consisting of seven different herbs: Radix Astragali, Radix Paeoniae Alba, Ramulus Cinnamomi, Fructus Jujubae, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Rhizoma Zingiberis Recens, and Saccharum Granorum.
The present study aims to evaluate the possible effects of HQJZT on cardiac function in acute myocardial infarction (AMI) and related mechanism.
AMI model was established by ligation of the left anterior descending coronary artery followed by one-week HQJZT treatment.
Survival rate was calculated.
Rat heart function was assessed by heart performance analysis system.
5-Triphenyltetrazolium chloride (TTC) staining was used to observe myocardial infarct size.
Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining and western blot were applied to evaluate tissue apoptotic level.
Treatment with high dose of HQJZT improved cardiac function, reduced infarct size, number of apoptotic cells and expression of apoptotic proteins, Bax (a proapoptotic protein), and increased expression of antiapoptotic protein, Bcl2.
However, enalapril (an angiotensin-converting enzyme inhibitor) treatment did not show marked improvement of these parameters.
Our present data suggest that HQJZT has potential therapeutic effects to improve cardiac function by regulation of apoptotic signaling pathway.
American Psychological Association (APA)
Bao, Ya-Ru& Jiang, Wen-Yi& Yu, Jia-Yu& Chen, Jing-Wei& Zhang, Guo-Xing. 2020. Traditional Chinese Medicine Formulation Huangqi Jianzhong Tang Improves Cardiac Function after Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155562
Modern Language Association (MLA)
Bao, Ya-Ru…[et al.]. Traditional Chinese Medicine Formulation Huangqi Jianzhong Tang Improves Cardiac Function after Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155562
American Medical Association (AMA)
Bao, Ya-Ru& Jiang, Wen-Yi& Yu, Jia-Yu& Chen, Jing-Wei& Zhang, Guo-Xing. Traditional Chinese Medicine Formulation Huangqi Jianzhong Tang Improves Cardiac Function after Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155562