Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats
Joint Authors
Wang, Xiong
Ma, Li
Guo, Run-zhu
Ding, Qiao-yan
Meng, Jun-hua
Chen, Yong-gang
Wu, Jin-hu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prolactinomas are harmful to human health, and the clinical first-line treatment drug is bromocriptine.
However, 20% prolactinomas patients did not respond to bromocriptine.
Hordenine is an alkaloid separated from Fructus Hordei Germinatus, which showed significant antihyperprolactinemia activity in rats.
The aim of this study was to explore the effect and mechanism of hordenine on prolactinomas in rats.
The study used estradiol to induce prolactinomas, which caused the activation of the pituitary mitogen-activated protein kinase (MAPK) pathway in rats significantly.
The treatment of hordenine restored estradiol, induced the overgrowth of pituitary gland, and reduced the prolactin (PRL) accumulation in the serum and pituitary gland of rats by blocking the MAPK (p38, ERK1/2, and JNK) activation and production of inflammatory cytokines, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6).
The antiprolactinoma effect of hordenine was mediated by inhibiting the MAPK signaling pathway activation in rats.
American Psychological Association (APA)
Wang, Xiong& Guo, Run-zhu& Ma, Li& Ding, Qiao-yan& Meng, Jun-hua& Chen, Yong-gang…[et al.]. 2020. Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1155564
Modern Language Association (MLA)
Wang, Xiong…[et al.]. Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1155564
American Medical Association (AMA)
Wang, Xiong& Guo, Run-zhu& Ma, Li& Ding, Qiao-yan& Meng, Jun-hua& Chen, Yong-gang…[et al.]. Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1155564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155564
