![](/images/graphics-bg.png)
Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms
Joint Authors
Chen, Fangjun
Xu, Yifei
Wang, Jing
Yang, Xufeng
Cao, Hongying
Huang, Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In this study, we investigated the relaxation effect and mechanisms of patchouli alcohol (PA) on rat corpus cavernosum.
Corpus cavernosum strips were used in organ baths for isometric tension studies.
The results showed that PA demonstrated concentration-dependent relaxation effect on rat corpus cavernosum.
The relaxant response to PA was not influenced by tetrodotoxin and atropine while it was significantly inhibited by removal of endothelium.
L-NG-nitroarginine methyl ester (L-NAME, a nitric oxide synthase inhibitor) or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, a soluble guanylate cyclase inhibitor) significantly inhibited relaxation response to PA, whereas indomethacin (COX inhibitor) had no effect on PA-induced relaxation.
The treatment of endothelium-deprived corpus cavernosum with several potassium channel blockers including tetraethylammonium (TEA), 4-aminopyridine (4-AP), and glibenclamide had no effect on PA-induced relaxation.
Endothelium-deprived corpus cavernosal contractions induced by cumulative addition of Ca2+ to high KCl solution without CaCl2 were significantly inhibited by PA.
Also, PA improved relaxant capacity of sildenafil in rat corpus cavernosum.
In addition, the perfusion with PA significantly increased the levels of cGMP and expression of mRNA and protein of neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS).
Furthermore, intracavernous injection of PA enhanced the rise in intracavernous pressure in rats during cavernosal nerve electric stimulation.
In conclusion, PA relaxed the rat corpus cavernosum attributed to both endothelium-dependent and -independent properties.
While the former component was mostly involved in nitric oxide signaling pathway, the endothelium-independent mechanism involved in PA-induced relaxation was probably linked to calcium antagonism.
American Psychological Association (APA)
Chen, Fangjun& Xu, Yifei& Wang, Jing& Yang, Xufeng& Cao, Hongying& Huang, Ping. 2020. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155567
Modern Language Association (MLA)
Chen, Fangjun…[et al.]. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155567
American Medical Association (AMA)
Chen, Fangjun& Xu, Yifei& Wang, Jing& Yang, Xufeng& Cao, Hongying& Huang, Ping. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155567