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Clinicopathological Characteristics and Prognosis of Upper Gastric Cancer Patients in China: A 32-Year Single-Center Retrospective Clinical Study
Joint Authors
Wang, Peng-liang
Xu, Hui-mian
Gong, Yingbo
Zhu, Zhi
Zhang, Junyan
Huang, Jinyu
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
Upper or proximal gastric cancer occurs in the upper third of the stomach between the cardia and a line connecting the greater and lesser curvatures.
As it differs from other gastric cancers in pathology and prognosis, we evaluated patient and disease characteristics that might guide improved treatment and survival of upper gastric cancer.
Methods.
We conducted a retrospective analysis of 649 patients with upper gastric cancer and 1551 patients with lower gastric cancer and R0 radical surgery at our institution between January 1980 and December 2012.
Results.
Survival after radical surgery for upper gastric cancer was 77.8% at 1 year, 49.6% at 3 years, and 41.1% at 5 years.
The corresponding rates for lower gastric cancer were 85.9%, 60.0%, and 57.2% (p<0.001).
Upper gastric cancer had a poor prognosis.
Sex (p=0.036), tumor diameter (p=0.001), macroscopic type (p<0.001), pTM stage (p<0.001), tissue differentiation type (p=0.003), and serosal invasion (p=0.034) were independently associated with lymph node metastasis.
The macroscopic type (p=0.045), lymphovascular tumor emboli (p=0.021), and pTNM stage were independently associated with recurrence and metastasis.
Survival of 333 patients with D2 total gastrectomy was 81.3% at 1 year, 54.4% at 3 years, and 45.2% at 5 years.
The corresponding rates for 316 proximal gastrectomy patients were 75.4%, 44.9%, and 36.7%.
Radical total gastrectomy had better survival than radical proximal resection.
Conclusions.
Upper gastric cancers were more aggressive, had a worse prognosis, and were more prone to recurrence and metastasis compared with lower gastric cancers.
Survival was better after total gastrectomy than after proximal resection.
American Psychological Association (APA)
Gong, Yingbo& Wang, Peng-liang& Zhu, Zhi& Zhang, Junyan& Huang, Jinyu& Xu, Hui-mian. 2019. Clinicopathological Characteristics and Prognosis of Upper Gastric Cancer Patients in China: A 32-Year Single-Center Retrospective Clinical Study. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1155579
Modern Language Association (MLA)
Gong, Yingbo…[et al.]. Clinicopathological Characteristics and Prognosis of Upper Gastric Cancer Patients in China: A 32-Year Single-Center Retrospective Clinical Study. Gastroenterology Research and Practice No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1155579
American Medical Association (AMA)
Gong, Yingbo& Wang, Peng-liang& Zhu, Zhi& Zhang, Junyan& Huang, Jinyu& Xu, Hui-mian. Clinicopathological Characteristics and Prognosis of Upper Gastric Cancer Patients in China: A 32-Year Single-Center Retrospective Clinical Study. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1155579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155579