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Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1hi Monocytes
Joint Authors
Wu, Hongyan
Zhao, Xiang-An
Chen, Guangmei
Liu, Yong
Chen, Jin
Xiong, Yali
Tian, Chen
Jia, Bei
Wang, Guiyang
Xia, Juan
Chen, Yuxin
Wang, Jian
Yan, Xiaomin
Zhang, Zhaoping
Huang, Rui
Wu, Chao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Emodin, as a major active component of Rheum palmatum L.
and Polygonum cuspidatum, has been reported to have antifibrotic effect.
However, the mechanism of emodin on antifibrotic effect for liver fibrosis was still obscure.
In the present study, we aimed to investigate whether emodin can alleviate carbon tetrachloride- (CCl4-) induced liver fibrosis through reducing infiltration of Gr1hi monocytes.
Liver fibrosis was induced by intraperitoneal CCl4 injection in mice.
Mice in the emodin group received emodin treatment by gavage.
Pretreatment with emodin significantly protected mice from liver inflammation and fibrosis revealed by the decreased elevation of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as reduced hepatic necrosis and fibrosis by analysis of hematoxylin-eosin (HE) staining, Masson staining, α-smooth muscle actin (α-SMA), and collagen-I immunohistochemistry staining.
Further, compared to CCl4 group, mice in the emodin group showed significantly less intrahepatic infiltration of Gr1hi monocytes.
Moreover, emodin significantly inhibited hepatic expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), granulin (GRN), monocyte chemoattractant protein 1 (MCP-1), and chemokine ligand 7 (CCL7), which was in line with the decreased numbers of intrahepatic Gr1hi monocytes.
In conclusion, emodin can alleviate the degree of liver fibrosis by reducing infiltration of Gr1hi monocytes.
These results suggest that emodin is a promising candidate to prevent and treat liver fibrosis.
American Psychological Association (APA)
Zhao, Xiang-An& Chen, Guangmei& Liu, Yong& Wu, Hongyan& Chen, Jin& Xiong, Yali…[et al.]. 2018. Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1hi Monocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155610
Modern Language Association (MLA)
Zhao, Xiang-An…[et al.]. Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1hi Monocytes. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155610
American Medical Association (AMA)
Zhao, Xiang-An& Chen, Guangmei& Liu, Yong& Wu, Hongyan& Chen, Jin& Xiong, Yali…[et al.]. Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1hi Monocytes. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155610