Effects of Methanol Fraction from Leaves of Schinus terebinthifolius Raddi on Nociception and Spinal-Cord Oxidative Biomarkers in Rats with Neuropathic Pain
Joint Authors
Belló-Klein, Adriane
von Poser, Gilsane Lino
Scheid, Taína
Moraes, Maira Silmara
Henriques, Thiago Pereira
Riffel, Ana Paula Konzen
Ethur, Eduardo Miranda
Partata, Wania Aparecida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We determined the antioxidant potential of fractions obtained from leaves of Schinus terebinthifolius, a medicinal plant known in Brazil as aroeira, to select the fraction with the best yield and antioxidant performance.
These qualities were found in the methanol fraction (MeF), which was administered intraperitoneally (20 mg/kg/day) for 3 and 10 days to rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain.
The MeF increased the mechanical and thermal thresholds that had been lowered by CCI.
In parallel, the lumbosacral spinal cord showed an increase in superoxide dismutase but a decrease in glutathione peroxidase and glutathione-S-transferase activities in saline- and MeF-treated CCI rats.
Catalase activity decreased only in saline-treated CCI rats for 10 days.
Total thiols decreased in saline- and MeF-treated CCI rats.
Ascorbic acid increased in these rats at day 3 but only in saline-treated CCI rats at day 10.
No change was found in hydrogen peroxide and lipid hydroperoxide.
Open-field and elevated plus-maze tests and blood parameters of liver function did not change.
Thus, the MeF from leaves of S.
terebinthifolius has an antinociceptive action with no toxic effects, and it affects oxidant biomarkers in the spinal cord of rats with CCI.
American Psychological Association (APA)
Scheid, Taína& Moraes, Maira Silmara& Henriques, Thiago Pereira& Riffel, Ana Paula Konzen& Belló-Klein, Adriane& von Poser, Gilsane Lino…[et al.]. 2018. Effects of Methanol Fraction from Leaves of Schinus terebinthifolius Raddi on Nociception and Spinal-Cord Oxidative Biomarkers in Rats with Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155620
Modern Language Association (MLA)
Scheid, Taína…[et al.]. Effects of Methanol Fraction from Leaves of Schinus terebinthifolius Raddi on Nociception and Spinal-Cord Oxidative Biomarkers in Rats with Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1155620
American Medical Association (AMA)
Scheid, Taína& Moraes, Maira Silmara& Henriques, Thiago Pereira& Riffel, Ana Paula Konzen& Belló-Klein, Adriane& von Poser, Gilsane Lino…[et al.]. Effects of Methanol Fraction from Leaves of Schinus terebinthifolius Raddi on Nociception and Spinal-Cord Oxidative Biomarkers in Rats with Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1155620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155620