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Synthesis, Antimicrobial Properties, and Inhibition of Catalase Activity of 1,4-Naphtho- and Benzoquinone Derivatives Containing N-, S-, O-Substituted
Joint Authors
Sayil, Cigdem
Kurban, Semih
Deniz, Nahide Gulsah
Ozyurek, Mustafa
Guclu, Kubilay
Stasevych, Maryna
Zvarych, Viktor
Komarovska-Porokhnyavet, Olena
Novikov, Volodymyr
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A series of new 1,4-naphtho- and benzoquinone derivatives possessing N-, S-, O-substituted groups which has not been reported yet has been synthesized from 2,3-dichloro-1,4-naphthoquinone 1 and 2,3,5,6-tetrachlorocyclohexa-2,5-diene-1,4-dione 15 involving a Michael addition.
In the synthesized compounds, antimicrobial activity at low concentrations against Escherichia coli B-906, Staphylococcus aureus 209-P, and Mycobacterium luteum B-917 bacteria and Candida tenuis VKM Y-70 and Aspergillus niger F-1119 fungi in comparison with controls was identified.
2-Chloro-3-((2-(piperidin-1-yl)ethyl)amino)naphthalene-1,4-dione 3g and 2,5-dichloro-3-ethoxy-6-((2,4,6-trifluorophenyl)amino)cyclohexa-2,5-diene-1,4-dione 17 were the most potent, with a minimum inhibitory concentration value of 15.6 μg/mL against test-culture M.
luteum and S.
aureus, respectively.
Furthermore, in this work, a catalase activity of benzo- and naphthoquinone derivatives was examined for the first time.
The catalase activity of benzo- and naphthoquinone derivatives was determined, showing that compound 3g had significant inhibition activity for catalase enzyme.
American Psychological Association (APA)
Kurban, Semih& Deniz, Nahide Gulsah& Sayil, Cigdem& Ozyurek, Mustafa& Guclu, Kubilay& Stasevych, Maryna…[et al.]. 2019. Synthesis, Antimicrobial Properties, and Inhibition of Catalase Activity of 1,4-Naphtho- and Benzoquinone Derivatives Containing N-, S-, O-Substituted. Heteroatom Chemistry،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1155625
Modern Language Association (MLA)
Kurban, Semih…[et al.]. Synthesis, Antimicrobial Properties, and Inhibition of Catalase Activity of 1,4-Naphtho- and Benzoquinone Derivatives Containing N-, S-, O-Substituted. Heteroatom Chemistry No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1155625
American Medical Association (AMA)
Kurban, Semih& Deniz, Nahide Gulsah& Sayil, Cigdem& Ozyurek, Mustafa& Guclu, Kubilay& Stasevych, Maryna…[et al.]. Synthesis, Antimicrobial Properties, and Inhibition of Catalase Activity of 1,4-Naphtho- and Benzoquinone Derivatives Containing N-, S-, O-Substituted. Heteroatom Chemistry. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1155625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155625