Computational Studies of 4-Formylpyridinethiosemicarbazone and Structural and Biological Studies of Its Ni(II) and Cu(II) Complexes
Joint Authors
Sripathi, Mydhili P.
Berely, Sireesha
Ramana Reddy, Chittireddy Venkata
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To understand the stability, chelation behaviour, and biological activity of 4-Formylpyridinethiosemicarbazone (H4FPT), it is important to recognize its interactive geometry.
Hence, computational studies on geometrically optimized structures of thione and thiol forms of H4FPT were performed.
Binary metal complexes of the ligand, H4FPT (L) with the Ni(II) and Cu(II) metal ions (M), were synthesized and characterized by various spectroanalytical techniques as elemental analysis, molar conductance, magnetic susceptibility measurements, LC-MS, TGA, IR, UV-Visible, ESR, and powder XRD.
Elemental analysis, LC-MS, and TGA studies indicate 1:2 (ML2) composition for mononuclear Ni(II) complex and 1:1 (ML) composition for dinuclear Cu(II) complex.
Electronic absorption titrations, fluorescence quenching studies, and viscosity measurements suggest intercalative mode of binding of the complexes with calf thymus DNA (CT-DNA).
These complexes also promote hydrolytic cleavage of plasmid pBR322.
The ligand (H4FPT) and its complexes showed moderate-to-good activity against Gram-positive and Gram-negative bacterial strains.
The DPPH radical scavenging studies showed antioxidant nature of both complexes.
American Psychological Association (APA)
Sripathi, Mydhili P.& Berely, Sireesha& Ramana Reddy, Chittireddy Venkata. 2019. Computational Studies of 4-Formylpyridinethiosemicarbazone and Structural and Biological Studies of Its Ni(II) and Cu(II) Complexes. Heteroatom Chemistry،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155642
Modern Language Association (MLA)
Sripathi, Mydhili P.…[et al.]. Computational Studies of 4-Formylpyridinethiosemicarbazone and Structural and Biological Studies of Its Ni(II) and Cu(II) Complexes. Heteroatom Chemistry No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1155642
American Medical Association (AMA)
Sripathi, Mydhili P.& Berely, Sireesha& Ramana Reddy, Chittireddy Venkata. Computational Studies of 4-Formylpyridinethiosemicarbazone and Structural and Biological Studies of Its Ni(II) and Cu(II) Complexes. Heteroatom Chemistry. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1155642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155642