Efficacy of Traditional Chinese Medicine Regimen Jian Pi Qu Shi Formula for Refractory Patients with Idiopathic Membranous Nephropathy: A Retrospective Case-Series Study
Joint Authors
Shi, Bin
Zhang, Rong-rong
Liang, Ying
Wang, Xin-hui
Lang, Rui
Yu, Ren-huan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The treatment of adult refractory idiopathic membranous nephropathy with steroid and other immunosuppressant-resistant nephrotic syndromes can be a significant challenge.
We evaluated the efficacy and safety of the traditional Chinese medicine Jian Pi Qu Shi Formula (JPQSF) as a promising regimen.
Methods.
We analyzed 15 consecutive patients with biopsy-proven idiopathic membranous nephropathy who failed immunosuppressive therapy from October 2013 to January 2017.
JPQSF was administered orally two times per day, respectively, in the morning and at night for 6 months.
All patients had at least 1 year of follow-up.
The primary endpoints included complete or partial remission.
Secondary endpoints included change of clinical parameters and adverse events after 12 months of treatment.
Results.
After 12 months, complete remission was achieved in 13.3% of patients and partial remission in 66.7%, yielding a response rate of 80%.
Proteinuria, serum albumin, and cholesterol were improved significantly (P<0.001, P<0.001, and P<0.05, respectively).
After 1 year of treatment, proteinuria (mean ± SD) decreased from 5.93 ± 2.54 g per 24 h to 1.99 ± 1.17 g per 24 h (P<0.001).
No serious adverse events occurred during the observation.
Conclusions.
JPQSF may be an alternative therapeutic option for steroid and general immunosuppressant-resistant membranous nephrotic syndrome patients, with a favorable safety profile.
Larger and longer follow-up studies evaluating this regimen are warranted.
American Psychological Association (APA)
Shi, Bin& Zhang, Rong-rong& Liang, Ying& Wang, Xin-hui& Lang, Rui& Yu, Ren-huan. 2018. Efficacy of Traditional Chinese Medicine Regimen Jian Pi Qu Shi Formula for Refractory Patients with Idiopathic Membranous Nephropathy: A Retrospective Case-Series Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155644
Modern Language Association (MLA)
Shi, Bin…[et al.]. Efficacy of Traditional Chinese Medicine Regimen Jian Pi Qu Shi Formula for Refractory Patients with Idiopathic Membranous Nephropathy: A Retrospective Case-Series Study. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1155644
American Medical Association (AMA)
Shi, Bin& Zhang, Rong-rong& Liang, Ying& Wang, Xin-hui& Lang, Rui& Yu, Ren-huan. Efficacy of Traditional Chinese Medicine Regimen Jian Pi Qu Shi Formula for Refractory Patients with Idiopathic Membranous Nephropathy: A Retrospective Case-Series Study. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1155644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155644