Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK12 Signaling Pathway
Joint Authors
Zhang, Xiaolu
Liu, Juntian
Pang, Xiaoming
Zhao, Jingjing
Xu, Shouzhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aldosterone regulates the initiation and development of atherosclerosis which is identified as a chronic inflammatory disease by promoting the generation of C-reactive protein in vascular smooth muscle cells.
Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects.
Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored.
Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study.
The amount of C-reactive protein, reactive oxygen species, and the signaling pathway-related molecules generated were estimated.
We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway.
The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin.
American Psychological Association (APA)
Zhang, Xiaolu& Liu, Juntian& Pang, Xiaoming& Zhao, Jingjing& Xu, Shouzhu. 2020. Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK12 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155655
Modern Language Association (MLA)
Zhang, Xiaolu…[et al.]. Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK12 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1155655
American Medical Association (AMA)
Zhang, Xiaolu& Liu, Juntian& Pang, Xiaoming& Zhao, Jingjing& Xu, Shouzhu. Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK12 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155655