Ginsenoside Rh1 Alleviates HK-2 Apoptosis by Inhibiting ROS and the JNKp53 Pathways
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Cisplatin is widely used in the treatment of malignant patients; however, its adverse nephrotoxic effects limit its clinical use.
Ginsenoside Rh1 is a main component of ginseng and has many pharmaceutical effects, including immunomodulatory effects.
Objective.
The objective of this research is to assess the effects of ginsenoside Rh1 on a cisplatin-induced HK-2 injury model and to study its potential effect mechanisms.
Methods.
HK-2 cell vitality was assessed via Cell Counting Kit-8 (CCK-8) assay.
Carboxyfluorescein succinimidyl ester/propidium iodide (CFSF/PI) staining was used to detect the apoptosis of HK-2 cells.
ROS expression was detected by DCFDA.
The expressions of JNK, p53, caspase-3, Bax, and NGAL were detected by western blot.
Results.
Ginsenoside Rh1 was found to increase the vitality of HK-2 cells and inhibit ROS production and the apoptosis of HK-2 cells in a cisplatin-induced injury model.
Ginsenoside Rh1 was found to inhibit the expression of JNK, p53, caspase-3, Bax, and NGAL in a cisplatin-induced injury model.
Conclusion.
Ginsenoside Rh1 alleviated HK-2 apoptosis in a cisplatin-induced injury model by inhibiting ROS production and the JNK/p53 pathway.
Ginsenoside Rh1 may be a promising drug for the alleviation of cisplatin-induced nephrotoxicity in malignant patients.
American Psychological Association (APA)
Yang, Qi& Qian, Lin& Zhang, Song. 2020. Ginsenoside Rh1 Alleviates HK-2 Apoptosis by Inhibiting ROS and the JNKp53 Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155694
Modern Language Association (MLA)
Yang, Qi…[et al.]. Ginsenoside Rh1 Alleviates HK-2 Apoptosis by Inhibiting ROS and the JNKp53 Pathways. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155694
American Medical Association (AMA)
Yang, Qi& Qian, Lin& Zhang, Song. Ginsenoside Rh1 Alleviates HK-2 Apoptosis by Inhibiting ROS and the JNKp53 Pathways. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155694