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Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model
Joint Authors
Choi, Jae-Suk
Kim, Joo Wan
Seol, Du Jin
Choung, Jai Jun
Ku, Sae-Kwang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aim.
Kuseonwangdogo is a traditional Korean immunomodulatory polyherbal prescription.
However, there are no systemic findings on its complex immunomodulatory effects on in vivo models.
In this study, we observed the immunomodulatory effects of Kuseonwangdogo-based mixed herbal formula aqueous extracts (MHFe) on cyclophosphamide- (CPA-) induced immunosuppression mouse model.
Methods.
In total, 60 male 6-week-old ICR mice (10 mice/group) were selected based on body weight 24 h after the second CPA treatment and used in this experiment.
Twelve hours after the end of the last (fourth) oral administration of MHFe, the animals were sacrificed.
Results.
Following CPA treatment, a noticeable decrease in the body, thymus, spleen, and submandibular lymph node (LN) weights; white blood cell, red blood cell, platelet number, hemoglobin, and hematocrit concentrations; serum interferon-γ levels; splenic tumor necrosis factor-α, interleukin- (IL-) 1β, and IL-10 content; and peritoneal and splenic natural killer cell activities was observed.
Depletion of lymphoid cells in the thymic cortex, splenic white pulp, and submandibular LN-related atrophic changes were also observed.
However, these CPA-induced myelosuppressive signs were markedly and dose-dependently inhibited by the oral administration of 125, 250, and 500 mg/kg MHFe.
Conclusion.
MHFe can be a promising, potent immunomodulatory therapeutic agent for various immune disorders.
American Psychological Association (APA)
Kim, Joo Wan& Choi, Jae-Suk& Seol, Du Jin& Choung, Jai Jun& Ku, Sae-Kwang. 2018. Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155711
Modern Language Association (MLA)
Kim, Joo Wan…[et al.]. Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1155711
American Medical Association (AMA)
Kim, Joo Wan& Choi, Jae-Suk& Seol, Du Jin& Choung, Jai Jun& Ku, Sae-Kwang. Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155711