Effects of the Traditional Chinese Medicine Tang Luo Ning on Intestinal Flora and Oxidative Stress in Diabetic Rats
Joint Authors
Gao, Yanbin
Wei, Xiaoyi
Zong, Wenjing
Peng, Siyang
Zheng, Yalin
Liu, Ke
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To determine the effects of TLN on glycolipid metabolism, oxidative stress, and intestinal flora in diabetic rat.
Materials and Methods.
Thirty-five male Sprague-Dawley (SD) rats (180–200 g) were divided into two groups.
The normal group was fed a standard-chow diet, whereas, in the model group, diabetes was induced by intraperitoneal administration of streptozotocin (STZ) combined with a high-fat sucrose diet.
Then, the model group was randomly allocated to four groups: DM (diabetes model) and TLNH (TLN high dose), TLNL (TLN low dose), and NAC (N-acetylcysteine).
Rats in the TLNH, TLNL, and NAC groups were intragastrically administered TLN and NAC for 12 weeks.
Subsequently, their weights, fasting glucose levels, serum lipids, serum insulin, serum ROS, and intestinal flora were determined.
Results.
The weight and intestinal flora abundance of the DM group were significantly lower than those of the normal group, whereas their total serum cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), serum reactive oxygen species (ROS), and serum insulin (INS) levels were significantly higher than those of the normal group.
TC and LDL-C levels in the TLNL group and DM group were similar, whereas FBG, INS, and ROS levels in the TLNL group were obviously lower than those in the DM group.
Compared with the DM group, there was a significant increase in intestinal flora abundance in the TLNL group.
At the phylum level, the ratio of Firmicutes to Bacteroidetes (core microbiota) varied in all groups.
However, in the DM group, Firmicutes abundance decreased, whereas that of Bacteroidetes increased.
An opposite trend was observed in the TLN-treated groups.
Conclusions.
TLN, which showed a dose-dependent therapeutic effect, can effectively decrease serum lipid, serum insulin, blood glucose, and serum ROS levels.
It can also rebalance the ratio of Firmicutes to Bacteroidetes.
Furthermore, the low-dose TLN treatment was most efficacious.
American Psychological Association (APA)
Wei, Xiaoyi& Zong, Wenjing& Gao, Yanbin& Peng, Siyang& Liu, Ke& Zheng, Yalin. 2020. Effects of the Traditional Chinese Medicine Tang Luo Ning on Intestinal Flora and Oxidative Stress in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1155716
Modern Language Association (MLA)
Wei, Xiaoyi…[et al.]. Effects of the Traditional Chinese Medicine Tang Luo Ning on Intestinal Flora and Oxidative Stress in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1155716
American Medical Association (AMA)
Wei, Xiaoyi& Zong, Wenjing& Gao, Yanbin& Peng, Siyang& Liu, Ke& Zheng, Yalin. Effects of the Traditional Chinese Medicine Tang Luo Ning on Intestinal Flora and Oxidative Stress in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1155716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155716