Interspecies Anticancer and Antimicrobial Activities of Genus Solanum and Estimation of Rutin by Validated UPLC-PDA Method
Joint Authors
Parvez, Mohammad Khalid
Husain, Fohad Mabood
Alajmi, Mohamed Fahad
Alam, Perwez
Rehman, Md. Tabish
Khan, Azmat Ali
Siddiqui, Nasir Ali
Hussain, Afzal
Kalam, Mohd. Abul
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Solanaceae is one of the highly diverse plant families of which Solanum is the largest genera (1700 species) containing several pharmacological properties like anticancer and antimicrobial.
This motivated us to explore the anticancer (against HepG2, HEK-293, and MCF-7 cells) and antimicrobial (against S.
aureus, E.
coli, P.
aeruginosa, and C.
albicans) properties of S.
schimperianum, S.
villosum, S.
coagulans, S.
glabratum, S.
incanum, and S.
nigrum along with rutin estimation by UPLC-PDA method.
Of the studied Solanum extracts, S.
nigrum exhibited significant cytotoxic property against HepG2 (IC50: 20.4 μg/mL) and MCF-7 (IC50: 30.1 μg/mL); S.
coagulans showed toxicity against HepG2 (IC50: 28.4 μg/mL) and HEK-293 cells (IC50: 25.7 μg/mL) compared to 5-Fluorouracil (standard).
Compared to these, extracts of S.
coagulans and S.
glabratum exhibited relatively high antimicrobial potency (MIC: 0.4-1.6 mg/mL).
Nonetheless, all Solanum extracts significantly reduced the biofilm against PAO1-strain.
Rutin was detected in all extracts with the highest content (53.79 μg/mg) in S.
coagulans that supported its strong antimicrobial and anticancer properties.
Molecular docking analysis showing strong binding of rutin with human DNA and proteins (DNA Topoisomerase IIα and E.
coli DNA gyrase B) supported the anticancer and antimicrobial activities of Solanum species.
American Psychological Association (APA)
Alajmi, Mohamed Fahad& Alam, Perwez& Rehman, Md. Tabish& Husain, Fohad Mabood& Khan, Azmat Ali& Siddiqui, Nasir Ali…[et al.]. 2018. Interspecies Anticancer and Antimicrobial Activities of Genus Solanum and Estimation of Rutin by Validated UPLC-PDA Method. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155734
Modern Language Association (MLA)
Alajmi, Mohamed Fahad…[et al.]. Interspecies Anticancer and Antimicrobial Activities of Genus Solanum and Estimation of Rutin by Validated UPLC-PDA Method. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1155734
American Medical Association (AMA)
Alajmi, Mohamed Fahad& Alam, Perwez& Rehman, Md. Tabish& Husain, Fohad Mabood& Khan, Azmat Ali& Siddiqui, Nasir Ali…[et al.]. Interspecies Anticancer and Antimicrobial Activities of Genus Solanum and Estimation of Rutin by Validated UPLC-PDA Method. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155734