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Anti-Inflammatory and Antioxidant Properties of the Extract, Tiliroside, and Patuletin 3-O-β-D-Glucopyranoside from Pfaffia townsendii (Amaranthaceae)
Joint Authors
Kuraoka-Oliveira, Ângela Midori
Corrêa, Wallace Ribeiro
Serain, Alessandra Freitas
Aranha Netto, Leticia
Marinho, Jane V. N.
Júnior, Armando Jorge
Bernal, Laura Priscila Toledo
Salvador, Marcos José
Kassuya, Cândida Aparecida Leite
Arena, Arielle Cristina
Figueiredo de Santana Aquino, Diana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Brazilian ginseng, including Pfaffia townsendii, is used in popular medicine as a natural anti-inflammatory, tonic, analgesic, and antidiabetic agent.
In this study, we investigated the chemical composition and evaluated the antioxidant and anti-inflammatory activities of the P.
townsendii ethanolic extract as well as the major isolated glycoside flavonoids tiliroside and patuletin 3-O-β-D-glucopyranoside.
Chromatographic techniques and spectroscopic analysis were used for the isolation and identification of the major compounds.
The antioxidant potential was determined through DPPH and ORAC-FL assays.
The total phenolic content was measured using Folin-Ciocalteu reagent.
The anti-inflammatory activity was determined based on a model of paw edema and carrageenan- (Cg-) induced pleurisy.
We identified three phenolic acids, one carboxylic acid and two flavonoids, patuletin 3-O-β-D-glucopyranoside, and tiliroside.
The ethanol crude extracts, partitions and isolated flavonoids (4581 μmol of Trolox equivalents/g of extract in ORAC and a SC50 of approximately 31.9 μg/mL in the DPPH assay) demonstrated antioxidant activity, and the ethanolic extract as well as isolated flavonoids inhibited paw edema induced by Cg and leukocyte migration in the Cg-induced pleurisy model.
The extract, tiliroside, and patuletin 3-O-β-D-glucopyranoside obtained from P.
townsendii have therapeutic potential against oxidative stress-related and inflammatory disorders.
American Psychological Association (APA)
Corrêa, Wallace Ribeiro& Serain, Alessandra Freitas& Aranha Netto, Leticia& Marinho, Jane V. N.& Arena, Arielle Cristina& Figueiredo de Santana Aquino, Diana…[et al.]. 2018. Anti-Inflammatory and Antioxidant Properties of the Extract, Tiliroside, and Patuletin 3-O-β-D-Glucopyranoside from Pfaffia townsendii (Amaranthaceae). Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155743
Modern Language Association (MLA)
Corrêa, Wallace Ribeiro…[et al.]. Anti-Inflammatory and Antioxidant Properties of the Extract, Tiliroside, and Patuletin 3-O-β-D-Glucopyranoside from Pfaffia townsendii (Amaranthaceae). Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155743
American Medical Association (AMA)
Corrêa, Wallace Ribeiro& Serain, Alessandra Freitas& Aranha Netto, Leticia& Marinho, Jane V. N.& Arena, Arielle Cristina& Figueiredo de Santana Aquino, Diana…[et al.]. Anti-Inflammatory and Antioxidant Properties of the Extract, Tiliroside, and Patuletin 3-O-β-D-Glucopyranoside from Pfaffia townsendii (Amaranthaceae). Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155743