Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Suppresses Migration of Bone-Metastatic Breast Cancer Cells via OPN-FAKERKNF-κB Axis
Joint Authors
Zhang, Dan-Dan
Yang, Yue
Fang, Ting
Yan, Ying-Xuan
Lv, Ya-Xin
Chang, Qing-Qi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hedyotis diffusa plus Scutellaria barbata is a couplet of medicinal that has been commonly used to treat inflammation-related diseases and various types of tumors.
However, the effect of this couplet on tumor cell migration has not been elucidated.
With the aid of MCF-7-BOM, a bone-metastatic subline of ER + breast cancer MCF-7, we showed that ethyl acetate fraction extracted at an equal weight ratio of Hedyotis diffusa plus Scutellaria barbata (EA11) inhibited cell migration of MCF-7-BOM in a concentration-dependent manner.
To define the underlying molecular mechanism, we revealed that EA11 reduced the expression of osteopontin (OPN) and interfered with the FAK/ERK/NF-κB signaling pathways, which are both critical for breast cancer bone metastasis.
This study strongly suggested EA11 may represent a potential therapeutic agent against bone metastasis of breast cancer.
American Psychological Association (APA)
Fang, Ting& Yan, Ying-Xuan& Yang, Yue& Lv, Ya-Xin& Chang, Qing-Qi& Zhang, Dan-Dan. 2020. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Suppresses Migration of Bone-Metastatic Breast Cancer Cells via OPN-FAKERKNF-κB Axis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155774
Modern Language Association (MLA)
Fang, Ting…[et al.]. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Suppresses Migration of Bone-Metastatic Breast Cancer Cells via OPN-FAKERKNF-κB Axis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1155774
American Medical Association (AMA)
Fang, Ting& Yan, Ying-Xuan& Yang, Yue& Lv, Ya-Xin& Chang, Qing-Qi& Zhang, Dan-Dan. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Suppresses Migration of Bone-Metastatic Breast Cancer Cells via OPN-FAKERKNF-κB Axis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1155774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155774