Effect of Yin-Xing-Tong-Zhi Tablets on Improving Vascular Cognitive Impairment No Dementia
Joint Authors
Liao, Weilong
Gao, Penglin
Liu, Te
Zhu, Wei
Gao, Qi
Pan, Weidong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Observe the effect of the Chinese herbal extracts, Yin-Xing-Tong-Zhi, in tablet form, on improving vascular cognitive impairment no dementia (VCIND).
Methods.
Sixty-eight patients with VCIND were divided randomly into treatment and placebo groups with oral administration of Yin-Xing-Tong-Zhi tablets (YXTZTs) or placebo, respectively, for 24 weeks.
Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog) subscale score, MMSE score, Clinician’s Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus) score, expression of interleukin- (IL-) 6, IL-8, and tumor necrosis factor- (TNF-) α in serum, and variation of blood-lipid levels were evaluated at different time points.
Results.
At weeks 12 and 24, the scores for the ADAS-Cog, CIBIC-Plus, and MMSE of the treatment group were significantly lower than those of the control group (P<0.05).
All clinical scales at week 24 of the control group were significantly different from those before treatment (P<0.05).
Expression of IL-6, IL-8, and TNF-α in the two groups was reduced significantly with variation of the clinical scales of cognitive impairment.
Conclusion.
YXTZTs may delay the development of cognitive impairment in VCIND patients by modulating expression of VCIND-associated proinflammatory factors.
American Psychological Association (APA)
Pan, Weidong& Zhu, Wei& Gao, Qi& Liao, Weilong& Gao, Penglin& Liu, Te. 2018. Effect of Yin-Xing-Tong-Zhi Tablets on Improving Vascular Cognitive Impairment No Dementia. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1155800
Modern Language Association (MLA)
Pan, Weidong…[et al.]. Effect of Yin-Xing-Tong-Zhi Tablets on Improving Vascular Cognitive Impairment No Dementia. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1155800
American Medical Association (AMA)
Pan, Weidong& Zhu, Wei& Gao, Qi& Liao, Weilong& Gao, Penglin& Liu, Te. Effect of Yin-Xing-Tong-Zhi Tablets on Improving Vascular Cognitive Impairment No Dementia. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1155800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155800