Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials
Joint Authors
Wang, Haiyan
Qin, Lingling
Song, Yanan
Gao, Saiyue
Wu, Lili
Liu, Tonghua
Li, Mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Objective.
The aim of this study was to review existing evidence on the efficiency and safety of Chinese herbal medicine for the treatment of prediabetes.
Methods.
Randomized controlled trials (RCTs) of Chinese herbal medicine (CHM) to treat prediabetes were searched in the following databases from their inception date onwards until 2 May 2020: MEDLINE, Cochrane, EMBASE, Web of Science, EBSCO, CINAHL, CNKI, VIP database, CBM, and Wanfang database.
Quality assessment of included trials was accessed according to the guidance in Cochrane.
Researchers independently assessed the validity of included trials and extracted outcome data for synthesis.
RevMan 5.3 was used for the meta-analysis.
Results.
Twenty-two RCTs including 3923 participants were included in the study.
Our findings upon the 22 RCTs showed CHM is effective in the treatment of prediabetes, which can statistically reduce the incidence of diabetes (RR = 0.48; 95% CI = (0.41, 0.57); P<0.001), increase the incidence of normalization of prediabetes (RR = 1.76; 95% CI = (1.57, 1.96); P<0.001), and lower FPG (MD = −0.38; 95% CI = (−0.60, −0.16); P<0.001), 2hPG (MD = −1.13; 95% CI = (−1.60, −0.67); P<0.001), TG (MD = −0.23; 95% CI = (−0.33, −0.13); P<0.001), TC (MD = −0.34; 95% CI = (−0.52, −0.16); P<0.001), and BMI (MD = −0.48; 95% CI = (−0.78, −0.18); P<0.001) after treatment, and there was no difference of HbA1c (P>0.05).
Conclusion.
CHM is effective for the treatment of prediabetes.
CHM can statistically reduce the incidence of diabetes, increase the incidence of normalization of prediabetes, and lower the FPG, 2hPG, TG, TC, and BMI levels, but with no significant difference in HbA1c.
In addition, CHM was relatively safe in clinical practice.
More high-quality RCTs should be conducted to strengthen the finding.
American Psychological Association (APA)
Song, Yanan& Wang, Haiyan& Qin, Lingling& Li, Mei& Gao, Saiyue& Wu, Lili…[et al.]. 2020. Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1155855
Modern Language Association (MLA)
Song, Yanan…[et al.]. Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1155855
American Medical Association (AMA)
Song, Yanan& Wang, Haiyan& Qin, Lingling& Li, Mei& Gao, Saiyue& Wu, Lili…[et al.]. Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1155855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155855