Protective Effect of Electroacupuncture at Zusanli on Myocardial Injury in Septic Rats
Joint Authors
Shi, Xian
Zhang, Lijian
Huang, Zhenjun
Litscher, Daniela
Wang, Lu
Litscher, Gerhard
Hu, Sen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The protective effect of electroacupuncture (EA) at Zusanli points (ST36) on myocardial injury in a model of sepsis was observed.
Forty-eight male Sprague-Daley rats were subjected to sepsis by cecal ligation and puncture (CLP) and randomly divided into 4 groups (n=12; A: sepsis + EA; B: sepsis + sham acupuncture; C: sepsis + vagotomy; D: sepsis + vagotomy + EA).
Bilateral points were stimulated (2mA, 2-100 Hz) for 1 hour.
Abdominal vagotomy was performed in groups C and D.
At 6h after CLP, the plasma activity of creatine kinase-MB (CK-MB) was determined.
A part of cardiac muscle was harvested for evaluating levels of tumor necrosis factor (TNF-α), nitric oxide (NO), myeloperoxidase (MPO), and the rate of water content.
The activities of CK-MB, TNF-α, NO, and MPO and the rate of water content in group A were significantly lower than those of the other groups 6h after CLP.
EA after vagotomy showed less anti-inflammatory and protective effects.
The results indicated that EA obviously reduced the increased levels of the proinflammatory factors at 6h after CLP, and vagotomy could weaken or eliminate the effects of EA.
Cholinergic anti-inflammatory pathway is one of the main mechanisms of cardioprotective effect of EA.
American Psychological Association (APA)
Zhang, Lijian& Huang, Zhenjun& Shi, Xian& Hu, Sen& Litscher, Daniela& Wang, Lu…[et al.]. 2018. Protective Effect of Electroacupuncture at Zusanli on Myocardial Injury in Septic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1155912
Modern Language Association (MLA)
Zhang, Lijian…[et al.]. Protective Effect of Electroacupuncture at Zusanli on Myocardial Injury in Septic Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1155912
American Medical Association (AMA)
Zhang, Lijian& Huang, Zhenjun& Shi, Xian& Hu, Sen& Litscher, Daniela& Wang, Lu…[et al.]. Protective Effect of Electroacupuncture at Zusanli on Myocardial Injury in Septic Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1155912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155912