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Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1
Joint Authors
Ma, Xia
Guo, Zhenhuan
Zhang, Zhiqiang
Li, Xianghui
Liu, Yonglu
Zhao, Li
Wang, Xuefei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Porcine parvovirus (PPV) infection-induced apoptosis was recently identified as an important pathological factor in PPV-induced placental tissue damage, resulting in reproduction failure.
In the present study, we demonstrate the possible involvement of toll-like receptor (TLR) 4 and nuclear factor (NF)-κB inflammasome activation in PPV infection-induced apoptosis and the protective potential of ferulic acid (FA).
PPV infection significantly activated the expression levels of TLR4, NF-κB, MyD88, and interleukin (IL)-6.
However, FA ameliorated the pathological process, prevented histological alterations, and inhibited the apoptosis rate in porcine kidney (PK-15) cells infected with PPV.
Results.
FA inhibited PPV infection-induced inflammasome activation as shown by decreases in the expression of NF-κB, MyD88, and IL-6.
FA also downregulated nonstructural (NS) 1 protein expression in infected PK-15 cells.
Conclusions.
FA downregulated NS1 and TLR4 signaling, prevented the overproduction of reactive oxygen species, and suppressed the NF-κB inflammasome axis to inhibit PPV-induced apoptosis in PK-15 cells.
American Psychological Association (APA)
Ma, Xia& Guo, Zhenhuan& Zhang, Zhiqiang& Li, Xianghui& Liu, Yonglu& Zhao, Li…[et al.]. 2020. Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156002
Modern Language Association (MLA)
Ma, Xia…[et al.]. Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156002
American Medical Association (AMA)
Ma, Xia& Guo, Zhenhuan& Zhang, Zhiqiang& Li, Xianghui& Liu, Yonglu& Zhao, Li…[et al.]. Ferulic Acid Protects against Porcine Parvovirus Infection-Induced Apoptosis by Suppressing the Nuclear Factor-κB Inflammasome Axis and Toll-Like Receptor 4 via Nonstructural Protein 1. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156002