Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis
Joint Authors
Lee, Ji Yeon
Park, Jeong-Yong
Kim, Dong Hwi
Kim, Hyung Don
Ji, Yun-Jeong
Seo, Kyung Hye
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Reactive oxygen species (ROS), associated with oxidative stress, are involved in many biological processes such as apoptosis, necrosis, and autophagy.
Oxidative stress might induce neuronal damage via ROS generation, causing neurodegenerative diseases.
Erigeron annuus (EA) has antioxidant properties and could protect neurons from oxidative stress.
In this study, we investigated the protective effect of the aerial parts (EAA) and flowers (EAF) from EA on ROS-mediated apoptosis in pheochromocytoma 12 cells.
We quantified 18 types of phenolic compounds using high-performance liquid chromatography.
Pretreatment of the cells with EAA and EAF attenuated ROS generation and induced the expression of antioxidant enzymes such as superoxide dismutase 2, catalase, and glutathione peroxidase.
In addition, EAF reduced the expression of apoptotic proteins such as Bax/Bcl-xL, caspase-3, and caspase-8 to a greater extent than that with EAA.
These results suggested that the protective effect of EAF against oxidative stress-induced apoptosis might be due to the prevention of ROS generation mediated by oxidative enzymes.
American Psychological Association (APA)
Lee, Ji Yeon& Park, Jeong-Yong& Kim, Dong Hwi& Kim, Hyung Don& Ji, Yun-Jeong& Seo, Kyung Hye. 2020. Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156006
Modern Language Association (MLA)
Lee, Ji Yeon…[et al.]. Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156006
American Medical Association (AMA)
Lee, Ji Yeon& Park, Jeong-Yong& Kim, Dong Hwi& Kim, Hyung Don& Ji, Yun-Jeong& Seo, Kyung Hye. Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156006