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Pharmacokinetic Comparisons of Typical Constituents in Curcumae Rhizoma and Vinegar-Processed Curcumae Rhizoma after Oral Administration to Rats
Joint Authors
Pan, Zi-Hao
Gu, Wei
Li, Jin-ci
Ji, De
Li, Lin
Zhang, Ji
Yang, Jun-jie
Mao, Chun-qin
Lu, Tulin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The Raw Curcumae Rhizoma (R-CR), included in the Chinese Pharmacopoeia Edition 2015, is a well-known Chinese herbal medicine.
However, the vinegar-processed Curcumae Rhizoma (V-CR) is used more widely than R-CR.
The pharmacokinetics comparison of R-CR and V-CR after oral administration to rats is poorly understood.
A novel method, rapid resolution liquid chromatography-tandem mass spectrometry (RRLC-MS) coupled with a sensitive, specific, and convenient microdialysis sampling method, free from endogenous interference was developed in this research.
The extracts of R-CR and V-CR were administered orally to each group of rats.
The blood and liver microdialysis probes were positioned within the jugular vein toward the right atrium and the median lobe near the center of the liver, respectively.
Then, a double-peak phenomenon was observed in the concentration-time curves of curdione in R-CR group, while it was not observed in V-CR group.
The liver-to-blood distribution ratio of curdione in V-CR group increased significantly (P<0.05) compared to that of R-CR group.
However, compared with V-CR group, the pharmacokinetic parameters of curcumol exhibited no statistically significant differences from those of R-CR group.
These results indicate that vinegar-processed procedure has influence on the pharmacokinetic process of Curcumae Rhizoma in/ns.
RRLC-MS coupled with microdialysis system could be used to evaluate the pharmacokinetics of typical constituents in Curcumae Rhizoma after oral administration.
American Psychological Association (APA)
Gu, Wei& Li, Jin-ci& Ji, De& Li, Lin& Zhang, Ji& Pan, Zi-Hao…[et al.]. 2018. Pharmacokinetic Comparisons of Typical Constituents in Curcumae Rhizoma and Vinegar-Processed Curcumae Rhizoma after Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156035
Modern Language Association (MLA)
Gu, Wei…[et al.]. Pharmacokinetic Comparisons of Typical Constituents in Curcumae Rhizoma and Vinegar-Processed Curcumae Rhizoma after Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156035
American Medical Association (AMA)
Gu, Wei& Li, Jin-ci& Ji, De& Li, Lin& Zhang, Ji& Pan, Zi-Hao…[et al.]. Pharmacokinetic Comparisons of Typical Constituents in Curcumae Rhizoma and Vinegar-Processed Curcumae Rhizoma after Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156035