Anti-Helicobacter pylori and Anti-Inflammatory Effects and Constituent Analysis of Modified Xiaochaihutang for the Treatment of Chronic Gastritis and Gastric Ulcer
Joint Authors
Liu, Wei
Zhou, Aijun
Liu, Yanwen
Chen, Xin
Hu, Lijuan
Wu, Huanhuan
Chen, Shuhe
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Chronic gastritis and gastric ulcers are prevalent throughout the world and are considered to be a global health problem.
Modified Xiaochaihutang (MXCHT) prescription is broadly used in traditional medicine hospital for the treatment of gastritis.
In order to assess the anti-Helicobacter pylori (H.
pylori) effect of MXCHT, agar diffusion method in vitro and fluid dilution method for the minimal inhibitory concentration (MIC) were established.
The anti-inflammatory effects were then evaluated using mouse ear edema model and rat paw edema model.
The ethanol-induced gastric ulcer method was employed to verify the gastroprotective effect of active extracts in MXCHT.
HPLC-TOF-MS/MS was used for analyzing the possible active constituents after oral administration of effective extracts in ethanol-induced gastric ulcer models.
MXCHT and 4 different extracts of the bacterial inhibition diameter and MIC were dramatically decreased compared with control group, showing anti-Helicobacter pylori effects.
High dose groups of MXCHT, water extract, EtOAc extract, and n-BuOH extract displayed significant anti-inflammatory effects in xylene-induced mouse ear edema model and carrageenan-induced rat paw edema model test.
MXCHT and all active extracts exhibited gastroprotective activity and prevented gastric lesions induced by ethanol in rats.
4 prototype components and 4 metabolites were identified after oral administration of EtOAc extract.
In addition, 6 prototype components and 6 metabolites were identified in n-BuOH extract.
MXCHT, EtOAc extract, and n-BuOH extract demonstrate gastroprotective effects through anti-Helicobacter pylori and anti-inflammatory activities.
Thus, this prescription may be a suitable natural source for the prevention and treatment of chronic gastritis and gastric ulcers.
American Psychological Association (APA)
Chen, Xin& Hu, Lijuan& Wu, Huanhuan& Liu, Wei& Chen, Shuhe& Zhou, Aijun…[et al.]. 2018. Anti-Helicobacter pylori and Anti-Inflammatory Effects and Constituent Analysis of Modified Xiaochaihutang for the Treatment of Chronic Gastritis and Gastric Ulcer. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1156038
Modern Language Association (MLA)
Chen, Xin…[et al.]. Anti-Helicobacter pylori and Anti-Inflammatory Effects and Constituent Analysis of Modified Xiaochaihutang for the Treatment of Chronic Gastritis and Gastric Ulcer. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1156038
American Medical Association (AMA)
Chen, Xin& Hu, Lijuan& Wu, Huanhuan& Liu, Wei& Chen, Shuhe& Zhou, Aijun…[et al.]. Anti-Helicobacter pylori and Anti-Inflammatory Effects and Constituent Analysis of Modified Xiaochaihutang for the Treatment of Chronic Gastritis and Gastric Ulcer. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1156038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156038