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Different Forms of Ursolic Acid and Their Effect on Liver Regeneration
Joint Authors
Tichá, Alena
Žaloudková, Lenka
Nekvindová, Jana
Pavlíková, Ladislava
Zadák, Zdeněk
Živný, Pavel
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to determine the effect of natural and encapsulated sources of ursolic acid on liver regeneration.
Four ursolate sources were tested.
Two forms of ursolic acid encapsulates were combined with cyclodextrins, i.e., gamma-CD (gCD) and beta-CD, and two natural sources were adjusted by homogenization (HAP) and micronization of apple peel using Jonagold apples.
All ursolate forms were applied intragastrically in daily doses of 20 mg for 7 days.
Laboratory rats were fed with standard laboratory diet.
Further, gCD and MAP were also tested with a high-fat diet (6 weeks).
Partial hepatectomy (PH) was performed 24 hours before the end of the experiment.
The concentration of plasma hepatocyte growth factor (HGF) was determined with an immunoassay; simultaneously, the expression of HGF and CYP7A1 in the liver was quantified through qPCR.
HGF expression and plasma levels were significantly increased 24 hours after PH in both the HAP (p=0.038) and HFgCD groups (p=0.036), respectively.
The correlation between HGF expression and plasma values was significant (p=0.04).
The positive effects on liver regeneration were found in both the gCD and HAP forms of ursolic acid, whose effects were confirmed through the upregulation of HGF.
American Psychological Association (APA)
Žaloudková, Lenka& Tichá, Alena& Nekvindová, Jana& Pavlíková, Ladislava& Zadák, Zdeněk& Živný, Pavel. 2020. Different Forms of Ursolic Acid and Their Effect on Liver Regeneration. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156044
Modern Language Association (MLA)
Žaloudková, Lenka…[et al.]. Different Forms of Ursolic Acid and Their Effect on Liver Regeneration. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1156044
American Medical Association (AMA)
Žaloudková, Lenka& Tichá, Alena& Nekvindová, Jana& Pavlíková, Ladislava& Zadák, Zdeněk& Živný, Pavel. Different Forms of Ursolic Acid and Their Effect on Liver Regeneration. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156044