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Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer
Joint Authors
Feng, Zhe
Feng, Ziyi
Han, Jie
Cheng, Weimin
Su, Bo
Mo, Jian
Feng, XinJian
Feng, Sitan
Chen, GuoJian
Huang, Peng
Huang, Long
Cui, Zhenwei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Shenling Baizhu additive powder (SLBZ-AP), a formulation of a variety of natural medicinal plants, has clinical efficacy in treating cancers in previous studies.
We explored the effect of SLBZ-AP in bone metastasis of lung cancer (BMLC) mice, and the possible mechanism involved was further investigated in the present study.
Mice model of BMLC was made and treated with SLBZ-AP.
Pain behavioral tests were performed to explore the effect on BMLC-induced pain in mice.
TUNEL staining was used to investigate apoptosis.
The mRNA expression of markers in the PI3K/Akt/mTOR pathway was measured by qPCR, and protein expression was detected by western blotting and immunohistochemistry analysis.
SLBZ-AP relieved BMLC-induced pain and prolonged animals’ survival, promoted cell apoptosis in the marrow from the tibia of BMLC mice, and inhibited mRNA and protein expression of AKT, mTOR, P70S6, and VEGF, as well as protein expression of p-AKT, p-mTOR, p-P70S6, and VEGF upregulation in the marrow of tibia induced by BMLC, an effect which was similar to rapamycin.
Our results suggested that SLBZ-AP may have antinociceptive effect and prolong survival of BMLC mice at least partially by inhibiting cell proliferation and promoting apoptosis through the PI3K/Akt/mTOR signaling pathway.
SLBZ-AP may be a potential candidate for BMLC therapy.
American Psychological Association (APA)
Feng, Zhe& Feng, Ziyi& Han, Jie& Cheng, Weimin& Su, Bo& Mo, Jian…[et al.]. 2020. Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156055
Modern Language Association (MLA)
Feng, Zhe…[et al.]. Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156055
American Medical Association (AMA)
Feng, Zhe& Feng, Ziyi& Han, Jie& Cheng, Weimin& Su, Bo& Mo, Jian…[et al.]. Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156055