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Anti-Inflammatory Activity of Rg3-Enriched Korean Red Ginseng Extract in Murine Model of Sepsis
Joint Authors
Saba, Evelyn
Jeong, Da-Hye
Irfan, Muhammad
Lee, Yuan Yee
Park, Chae-Kyu
Park, Sang-Joon
Rhee, Man Hee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ginseng has therapeutic effects on various bodily disorders ranging from minor inflammation to major cardiovascular diseases.
In our study, we explored the anti-inflammatory effects of Rg3-enriched red ginseng extract (Rg3-RGE), a ginsenoside belonging to the panaxadiol group.
We employed nitric oxide assay (NO) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), western blot, and hematoxylin and eosin staining (H&E) to elucidate the anti-inflammatory activity of Rg3-RGE.
Rg3-RGE potently suppressed NO production in the murine macrophage cell line, RAW 264.7 cells, without any cytotoxicity across dosages.
Additionally, it inhibited the mRNA expression of proinflammatory mediators and cytokines like iNOS, COX-2, IL-1β, IL-6, and TNF-α.
Moreover it also inhibited the levels of malondialdehyde levels in serum of septic shock mice.
Immunoblot analysis showed that Rg3-RGE induced anti-inflammatory signal transduction via the NF-κB and MAPK pathways.
A remarkable attenuation of inflammation by oral treatment with Rg3-RGE in mice was observed in the survival study.
The in vivo study using a septic shock mouse model also showed similar results as the in vitro study.
Our findings suggest that Rg3-RGE can potentially be a potent anti-inflammatory agent that likely mediates its anti-inflammatory effects via the NF-κB and MAPK pathways.
American Psychological Association (APA)
Saba, Evelyn& Jeong, Da-Hye& Irfan, Muhammad& Lee, Yuan Yee& Park, Sang-Joon& Park, Chae-Kyu…[et al.]. 2018. Anti-Inflammatory Activity of Rg3-Enriched Korean Red Ginseng Extract in Murine Model of Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156059
Modern Language Association (MLA)
Saba, Evelyn…[et al.]. Anti-Inflammatory Activity of Rg3-Enriched Korean Red Ginseng Extract in Murine Model of Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156059
American Medical Association (AMA)
Saba, Evelyn& Jeong, Da-Hye& Irfan, Muhammad& Lee, Yuan Yee& Park, Sang-Joon& Park, Chae-Kyu…[et al.]. Anti-Inflammatory Activity of Rg3-Enriched Korean Red Ginseng Extract in Murine Model of Sepsis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156059