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Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews
Joint Authors
Park, Minjung
Lee, Boram
Kwon, Chan-Young
Kim, Suran
Lee, Jaesuk
Kim, Namkwen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objectives.
Herbal medicine (HM) is attracting attention for treating atopic dermatitis (AD).
This overview was conducted to summarize and critically evaluate the current systematic reviews (SRs) on HM for the treatment of AD.
Methods.
Through comprehensive searches, all relevant SRs on HM for AD published until May 2020 were included.
The quality of included SRs was assessed using the AMSTAR-2 tool.
Moreover, original randomized controlled trials (RCTs) included in the SRs were resynthesized to investigate the efficacy and safety of oral HM for AD.
The quality of evidence for the main findings was evaluated using the GRADE approach.
Results.
Nine SRs were included in this overview.
HM showed significantly better efficacy in terms of total effective rate (TER), itching and sleep symptom scores, quality of life, and the dose of topical treatment used compared with placebo.
HM as a monotherapy and/or an adjunctive therapy to conventional medication (CM) showed significantly better results on the efficacy, symptom relief, and some laboratory parameters related to the inflammatory response.
The methodological quality was generally low.
When 58 original RCTs were reanalyzed, HM showed significantly lower SCORing Atopic Dermatitis (SCORAD) score and higher TER than the placebo or CM.
In terms of the safety profile, HM was not significantly different from the placebo and was better than CM.
The quality of evidence ranged from “moderate” to “very low.” Conclusion.
The results suggested that HM as a monotherapy or an adjunctive therapy is promising for the treatment of AD.
However, due to low methodological quality and low quality of evidence, further rigorous, well-designed, high-quality SRs, and RCTs are needed to make clinical recommendations on HM use.
American Psychological Association (APA)
Kwon, Chan-Young& Lee, Boram& Kim, Suran& Lee, Jaesuk& Park, Minjung& Kim, Namkwen. 2020. Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1156060
Modern Language Association (MLA)
Kwon, Chan-Young…[et al.]. Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1156060
American Medical Association (AMA)
Kwon, Chan-Young& Lee, Boram& Kim, Suran& Lee, Jaesuk& Park, Minjung& Kim, Namkwen. Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1156060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156060