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Effects of Processed Polygonum multiflorum with KIOM Patent on Bone Remodeling-Related Protein Expression in Human Osteoblast-Like SaOS-2 Cells
Joint Authors
Shim, Ki-Shuk
Kim, Mi Hye
Kang, Youngmin
Kim, Dae Uk
Chung, Jae Yoon
Jin, Seong Chul
Komakech, Richard
Kim, Yong-Goo
Yang, Woong Mo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This present study evaluated the effects of processed P.
multiflorum on osteogenesis using Sarcoma osteogenic (SaOS-2) cell lines and osteoclastogenesis of bone marrow-derived macrophage cells (BMM) and to elucidate differences in effect on the expression of bone-related proteins between commercially sold P.
multiflorum and patented, in vitro-propagated Korea Institute of Oriental Medicine (KIOM) P.
multiflorum.
Raw P.
multiflorum and P.
multiflorum that were stir-baked and steamed in black bean juice were compared, and western blotting analysis was performed to investigate the expression of bone remodeling-related proteins in SaOS-2 cells.
In the cells treated with P.
multiflorum steamed in black bean juice, the expression of RANKL was decreased, whereas that of osteoprotegerin, alkaline phosphatase, Runx2, and osterix was increased.
Owing to these results, we conclude that processed P.
multiflorum can be used as an alternative treatment for bone diseases such as osteoporosis, osteopenia, periodontitis, and Paget’s disease.
American Psychological Association (APA)
Kim, Dae Uk& Chung, Jae Yoon& Jin, Seong Chul& Kim, Mi Hye& Komakech, Richard& Shim, Ki-Shuk…[et al.]. 2020. Effects of Processed Polygonum multiflorum with KIOM Patent on Bone Remodeling-Related Protein Expression in Human Osteoblast-Like SaOS-2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1156065
Modern Language Association (MLA)
Kim, Dae Uk…[et al.]. Effects of Processed Polygonum multiflorum with KIOM Patent on Bone Remodeling-Related Protein Expression in Human Osteoblast-Like SaOS-2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1156065
American Medical Association (AMA)
Kim, Dae Uk& Chung, Jae Yoon& Jin, Seong Chul& Kim, Mi Hye& Komakech, Richard& Shim, Ki-Shuk…[et al.]. Effects of Processed Polygonum multiflorum with KIOM Patent on Bone Remodeling-Related Protein Expression in Human Osteoblast-Like SaOS-2 Cells. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1156065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156065