The Derivative of Tripterygium wilfordii Hook F—Kunxian Capsule, Attenuated Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Joint Authors
Liu, Yafei
Chen, Zhe
Zhang, Jun-Jun
Xing, Guo-Lan
Zhang, Zhe
Tu, Shenghao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The study aimed to explore the efficacy and safety of Kunxian Capsule (KXC) in the treatment of rheumatoid arthritis (RA).
The randomized controlled trials (RCTs) comparing the effects of KXC in patients with RA were included in this study.
Weighted mean differences (MDs) were calculated for net changes by employing Review Manager meta-analysis software.
Nine RCTs were included in the systematic review with a total of 747 patients.
The overall effects showed that KXC alone or combined with disease-modifying antirheumatic and drugs decreased tender joint counts (P=0.02, MD = −1.07, 95% CI: −1.95 to −0.18), shortened duration of morning stiffness (P<0.0001, MD = −9.01, 95% CI: −13.08 to −4.93), lowered erythrocyte sedimentation rate (P<0.00001, MD = −5.27, 95% CI: −6.78 to −3.77), and reduced C-reactive protein (P<0.0001, MD = −5.04, 95% CI: −7.28 to −2.80).
The most common adverse events were gastrointestinal disturbances and abnormal liver function.
These results suggest that KXC is likely to be a more effective and safe candidate for treating RA compared with conventional therapies.
American Psychological Association (APA)
Liu, Yafei& Zhang, Zhe& Zhang, Jun-Jun& Chen, Zhe& Tu, Shenghao& Xing, Guo-Lan. 2020. The Derivative of Tripterygium wilfordii Hook F—Kunxian Capsule, Attenuated Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156069
Modern Language Association (MLA)
Liu, Yafei…[et al.]. The Derivative of Tripterygium wilfordii Hook F—Kunxian Capsule, Attenuated Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1156069
American Medical Association (AMA)
Liu, Yafei& Zhang, Zhe& Zhang, Jun-Jun& Chen, Zhe& Tu, Shenghao& Xing, Guo-Lan. The Derivative of Tripterygium wilfordii Hook F—Kunxian Capsule, Attenuated Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156069