Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage
Joint Authors
Tsim, Karl W. K.
Kong, Xiangpeng
Chen, Zhicong
Xia, Yingjie
Liu, Etta Y. L.
Ren, Haiqin
Wang, Cheng
Hu, Winnie W. H.
Dong, Tina T. X.
Pi, Rongbiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Corydalis Rhizoma (CR) is a commonly used traditional Chinese medicine for its potency in activating blood circulation and analgesia.
In clinic, CR extracts or components are commonly used in the treatment of myocardial ischemia, rheumatism, and dysmenorrhea with different types of inflammation.
However, due to different mechanism of pain and inflammation, the anti-inflammatory property of CR has not been fully revealed.
Here, the major chromatographic peaks of CR extracts in different extracting solvents were identified, and the anti-inflammatory activities of CR extracts and its major alkaloids were evaluated in LPS-treated macrophages by determining expressions of proinflammatory cytokines, IκBα and NF-κB.
The most abundant alkaloid in CR extract was dehydrocorydaline, having >50% of total alkaloids.
Besides, the anti-inflammatory activities of dehydrocorydaline and its related analogues were demonstrated.
The anti-inflammatory roles were revealed in LPS-treated cultured macrophages, including (i) inhibiting proinflammatory cytokines release, for example, TNF-α, IL-6; (ii) suppressing mRNA expressions of proinflammatory cytokines; (iii) promoting IκBα expression and suppressing activation of NF-κB transcriptional element; and (iv) reducing the nuclear translocation of NF-κB.
The results supported that dehydrocorydaline was the major alkaloid in CR extract, which, together with its analogous, accounted the anti-inflammatory property of CR.
American Psychological Association (APA)
Kong, Xiangpeng& Chen, Zhicong& Xia, Yingjie& Liu, Etta Y. L.& Ren, Haiqin& Wang, Cheng…[et al.]. 2020. Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156070
Modern Language Association (MLA)
Kong, Xiangpeng…[et al.]. Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1156070
American Medical Association (AMA)
Kong, Xiangpeng& Chen, Zhicong& Xia, Yingjie& Liu, Etta Y. L.& Ren, Haiqin& Wang, Cheng…[et al.]. Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1156070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156070