Glechoma curviflora Volatile Oil from Palestine: Chemical Composition and Neuroprotective, Antimicrobial, and Cyclooxygenase Inhibitory Activities
Joint Authors
Jaradat, Nidal
Abualhasan, Murad N.
Al-Maharik, Nawaf
Qneibi, Mohammad
Emwas, Nour
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The rise of the emergence of microbial resistance of antibiotics, the dangerous side effects of nonsteroidal anti-inflammatory drugs, and noncompetent medications of Alzheimer’s, Parkinson’s, and other neurodegenerative diseases prompt scientists to search for phytochemicals that could be utilized in the remedy of lethal diseases.
Glechoma curviflora (Boiss.) Kuntze (Nepeta curviflora) is a medicinal herb growing in the eastern parts of the Mediterranean Sea Basin and is widely consumed as a tea.
The leaves of this plant have been traditionally used for the treatment of various infectious diseases.
The current research was designed to identify the chemical composition of Glechoma curviflora (Boiss.) essential oil (EO) and to assess its antibacterial, antifungal, and cyclooxygenase inhibitory activities and the biophysical gating effect on AMPA receptors.
Twenty phytochemicals were identified from G.
curviflora leaves and flowers EO amounting to almost 100% of the total constituents using GC-MS technique, of which 1,6-dimethylspiro[4.5]decane (27.51%) 1, caryophyllene oxide (20.08%) 2, and β-caryophyllene (18.28%) 3 were the main constituents.
The biophysical properties’ effect from the plant extract on various AMPA-type receptors expressed in Human Embryonic Kidney (HEK293) cells was assessed by exploiting the whole-cell patch-clamp technique.
Microdilution assay was adopted for assessing the antimicrobial property against eight virulent microbial strains whilst the cyclooxygenase inhibition effect was accomplished utilizing COX inhibitory screening colorimetric assay G.
curviflora EO displayed potent activity against P.
aeruginosa (MIC = 1.25 μg/mL), S.
sonnei (MIC = 3.12 μg/mL), and E.
coli (MIC = 1.25 μg/mL), compared with ciprofloxacin (positive control) and potent antibacterial activity against S.
aureus, MRSA, S.
sonnei, E.
coli, and P.
aeruginosa compared to Ampicillin (2nd positive control).
It also showed anti-Candida (MIC = 6.25 μg/mL) and antimold (MIC = 3.125 μg/mL) activities compared with fluconazole (antifungal positive control).
Likewise, our results showed an inhibition and biophysical impact of G.
curviflora on all AMPARs subunits.
American Psychological Association (APA)
Al-Maharik, Nawaf& Jaradat, Nidal& Qneibi, Mohammad& Abualhasan, Murad N.& Emwas, Nour. 2020. Glechoma curviflora Volatile Oil from Palestine: Chemical Composition and Neuroprotective, Antimicrobial, and Cyclooxygenase Inhibitory Activities. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156071
Modern Language Association (MLA)
Al-Maharik, Nawaf…[et al.]. Glechoma curviflora Volatile Oil from Palestine: Chemical Composition and Neuroprotective, Antimicrobial, and Cyclooxygenase Inhibitory Activities. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156071
American Medical Association (AMA)
Al-Maharik, Nawaf& Jaradat, Nidal& Qneibi, Mohammad& Abualhasan, Murad N.& Emwas, Nour. Glechoma curviflora Volatile Oil from Palestine: Chemical Composition and Neuroprotective, Antimicrobial, and Cyclooxygenase Inhibitory Activities. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156071