![](/images/graphics-bg.png)
The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer
Joint Authors
Richard, Seidu A.
Kampo, Sylvanus
Sackey, Marian
Hechavarria, Maite Esquijarosa
Buunaaim, Alexis D. B.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Scorpion Buthus martensii Karsch -analgesic-antitumor peptide (BmK AGAP) has been used to treat diseases like tetanus, tuberculosis, apoplexy, epilepsy, spasm, migraine headaches, rheumatic pain, and cancer in China.
AGAP is a distinctive long-chain scorpion toxin with a molecular mass of 7142 Da and composed of 66 amino acids cross-linked by four disulfide bridges.
Voltage-gated sodium channels (VGSCs) are present in excitable membranes and partakes in essential roles in action potentials generation as compared to the significant function of voltage-gated calcium channels (VGCCs).
A total of nine genes (Nav1.1–Nav1.9) have been recognized to encode practical sodium channel isoforms.
Nav1.3, Nav1.7, Nav1.8, and Nav1.9 have been recognized as potential targets for analgesics.
Nav1.8 and Nav1.9 are associated with nociception initiated by inflammation signals in the neuronal pain pathway, while Nav1.8 is fundamental for neuropathic pain at low temperatures.
AGAP has a sturdy inhibitory influence on both viscera and soma pain.
AGAP potentiates the effects of MAPK inhibitors on neuropathic as well as inflammation-associated pain.
AGAP downregulates the secretion of phosphorylated p38, phosphorylated JNK, and phosphorylated ERK 1/2 in vitro.
AGAP has an analgesic activity which may be an effective therapeutic agent for pain management because of its downregulation of PTX3 via NF-κB and Wnt/beta-catenin signaling pathway.
In cancers like colon cancer, breast cancer, lymphoma, and glioma, rAGAP was capable of blocking the proliferation.
Thus, AGAP is a promising therapy for these tumors.
Nevertheless, research is needed with other tumors.
American Psychological Association (APA)
Richard, Seidu A.& Kampo, Sylvanus& Sackey, Marian& Hechavarria, Maite Esquijarosa& Buunaaim, Alexis D. B.. 2020. The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156078
Modern Language Association (MLA)
Richard, Seidu A.…[et al.]. The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156078
American Medical Association (AMA)
Richard, Seidu A.& Kampo, Sylvanus& Sackey, Marian& Hechavarria, Maite Esquijarosa& Buunaaim, Alexis D. B.. The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156078