Effect of Zishen Jiangtang Pill, a Chinese Herbal Product, on Rats with Diabetic Osteoporosis
Joint Authors
Chen, Jianping
Li, Huilin
Chu, Shufang
Zhao, Hengxia
Liu, Deliang
Liu, Xuemei
Qu, Xi
Li, Zengyin
Li, Jinhua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic osteoporosis (DO) is a complication of diabetes.
Zishen Jiangtang Pill (ZJP) is a Chinese herbal product which has been used in clinic to maintain blood glucose level and bone density for decades.
However, the evidence about its mechanism on diabetes and osteoporosis is still unknown.
The aim of this study is to investigate therapeutic effect of ZJP on DO in streptozotocin- (STZ-) induced rats.
Rats were randomly assigned to 4 groups: one control group (CON), one model group (MOD), and two ZJP treatment groups (1.5 and 3.0 g/kg/d).
All rats were treated for 8 weeks.
Results showed that ZJP decreased the blood glucose level during OGTT and prevented the changes of FBG and Fins.
Similarly, ZJP inhibited the changes of BCa, P, TRACP-5b, CTX-1, BALP, and BGP and the reduction of BMD.
In parallel, 1H-NMR metabolomic studies showed that ZJP significantly altered the metabolic fingerprints of blood and urine level.
These findings suggest that ZJP can effectively improve glucose metabolism, abnormal bone metabolism, and metabolic disorders in DO rats, which may be a useful alternative medicine for DO therapy.
American Psychological Association (APA)
Li, Huilin& Chu, Shufang& Zhao, Hengxia& Liu, Deliang& Liu, Xuemei& Qu, Xi…[et al.]. 2018. Effect of Zishen Jiangtang Pill, a Chinese Herbal Product, on Rats with Diabetic Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156108
Modern Language Association (MLA)
Li, Huilin…[et al.]. Effect of Zishen Jiangtang Pill, a Chinese Herbal Product, on Rats with Diabetic Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156108
American Medical Association (AMA)
Li, Huilin& Chu, Shufang& Zhao, Hengxia& Liu, Deliang& Liu, Xuemei& Qu, Xi…[et al.]. Effect of Zishen Jiangtang Pill, a Chinese Herbal Product, on Rats with Diabetic Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156108