Propolin C Inhibited Migration and Invasion via Suppression of EGFR-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Cancer Cells
Joint Authors
Pai, Jih-Tung
Lee, Yi-Chin
Chen, Si-Ying
Leu, Yann-Lii
Weng, Meng-Shih
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Controlling lung cancer cell migration and invasion via epithelial-to-mesenchymal transition (EMT) through the regulation of epidermal growth factor receptor (EGFR) signaling pathway has been demonstrated.
Searching biological active phytochemicals to repress EGFR-regulated EMT might prevent lung cancer progression.
Propolis has been used as folk medicine in many countries and possesses anti-inflammatory, antioxidant, and anticancer activities.
In this study, the antimigration and anti-invasion activities of propolin C, a c-prenylflavanone from Taiwanese propolis, were investigated on EGFR-regulated EMT signaling pathway.
Cell migration and invasion activities were dose-dependently suppressed by noncytotoxic concentration of propolin C.
Downregulations of vimentin and snail as well as upregulation of E-cadherin expressions were through the inhibition of EGFR-mediated phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) and extracellular signal-regulated kinase (ERK) signaling pathway in propolin C-treated cells.
In addition, EGF-induced migration and invasion were suppressed by propolin C-treated A549 lung cancer cells.
No significant differences in E-cadherin expression were observed in EGF-stimulated cells.
Interestingly, EGF-induced expressions of vimentin, snail, and slug were suppressed through the inhibition of PI3K/Akt and ERK signaling pathway in propolin C-treated cells.
Inhibition of cell migration and invasion by propolin C was through the inhibition of EGF/EGFR-mediated signaling pathway, followed by EMT suppression in lung cancer.
American Psychological Association (APA)
Pai, Jih-Tung& Lee, Yi-Chin& Chen, Si-Ying& Leu, Yann-Lii& Weng, Meng-Shih. 2018. Propolin C Inhibited Migration and Invasion via Suppression of EGFR-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1156111
Modern Language Association (MLA)
Pai, Jih-Tung…[et al.]. Propolin C Inhibited Migration and Invasion via Suppression of EGFR-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1156111
American Medical Association (AMA)
Pai, Jih-Tung& Lee, Yi-Chin& Chen, Si-Ying& Leu, Yann-Lii& Weng, Meng-Shih. Propolin C Inhibited Migration and Invasion via Suppression of EGFR-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1156111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156111