Jian-Pi-Yi-Shen Formula Regulates Inflammatory Cytokines Production in 56 Nephrectomized Rats via Suppression of NF-κB Activation
Joint Authors
Chen, Jianping
Liu, Xinhui
Li, Shunmin
Lu, Jiandong
Liao, Yijiao
Wang, Dongcai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Jian-Pi-Yi-Shen formula (JPYSF) is a Chinese herbal decoction used for treating chronic kidney disease (CKD) for over 20 years with good efficiency.
However, the mechanism lacks solid evidence.
In the present study, we tested the hypothesis that JPYSF may retard CKD progression via inhibition of inflammation in 5/6 nephrectomy (5/6 Nx) rat model.
The 5/6 Nx rats were randomly divided into 2 groups: 5/6 Nx group and JPYSF group.
Sham-operated rats served as control.
JPYSF (2.06 g/kg/d) were administrated by gavage to 5/6 Nx rats daily for 6 weeks.
Results showed that JPYSF treatment significantly improved kidney function and pathological injury in 5/6 Nx rats.
Multiplex analysis of cytokines revealed that JPYSF reduced proinflammatory cytokines and increased anti-inflammatory cytokine production.
Furthermore, JPYSF inhibited the activation of nuclear factor-kappa B (NF-κB) signaling pathway.
In conclusion, our data demonstrated that JPYSF remarkably retards development and progression of CKD in a 5/6 Nx rat model, which may be associated with inhibition of inflammation via NF-κB signaling pathway.
American Psychological Association (APA)
Lu, Jiandong& Liu, Xinhui& Liao, Yijiao& Wang, Dongcai& Chen, Jianping& Li, Shunmin. 2018. Jian-Pi-Yi-Shen Formula Regulates Inflammatory Cytokines Production in 56 Nephrectomized Rats via Suppression of NF-κB Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1156115
Modern Language Association (MLA)
Lu, Jiandong…[et al.]. Jian-Pi-Yi-Shen Formula Regulates Inflammatory Cytokines Production in 56 Nephrectomized Rats via Suppression of NF-κB Activation. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1156115
American Medical Association (AMA)
Lu, Jiandong& Liu, Xinhui& Liao, Yijiao& Wang, Dongcai& Chen, Jianping& Li, Shunmin. Jian-Pi-Yi-Shen Formula Regulates Inflammatory Cytokines Production in 56 Nephrectomized Rats via Suppression of NF-κB Activation. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1156115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156115