ErMiao San Inhibits Angiogenesis in Rheumatoid Arthritis by Suppressing JAKSTAT Signaling Pathways
Joint Authors
Qin, Qingxia
He, Lianhua
He, Juan
Wang, Han
Hu, Yiping
He, Wencheng
Xu, Bihua
Zhou, Gengmin
Shan, Hongying
Yang, Bo
Wang, Qingwen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
ErMiao San (EMS) is composed of the Cortex Phellodendri chinensis and Atractylodes lancea, and it has the function of eliminating heat and excreting dampness in terms of traditional Chinese medicine to damp heat syndrome.
Previous reports indicate that EMS possesses anti-inflammatory activity; however, its action on angiogenesis of rheumatoid arthritis (RA) has not been clarified.
The present study aims to determine the antiangiogenic activity of EMS in collagen-induced arthritis (CIA) mice and in various angiogenesis models.
Our data showed that EMS (5 g/kg) markedly reduced the immature blood vessels in synovial membrane tissues of inflamed joints from CIA mice.
It also inhibited vascular endothelial growth factor (VEGF)-induced microvessel sprout formation ex vivo.
Meanwhile, EMS suppressed VEGF-induced migration, invasion, adhesion, and tube formation of human umbilical vein endothelial cells (HUVECs).
Moreover, EMS significantly reduced the expression of angiogenic activators including interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) in synovium of CIA mice.
More interestingly, EMS blocked the autophosphorylation of VEGF-induced JAK1, STAT1, and STAT6 in CIA mice and VEGF-induced HUVECs.
These findings suggest for the first time that EMS possesses the antiangiogenic effect in RA in vivo, ex vivo, and in vitro by interrupting the targeting of JAK/STAT activation.
American Psychological Association (APA)
He, Lianhua& Qin, Qingxia& He, Juan& Wang, Han& Hu, Yiping& He, Wencheng…[et al.]. 2020. ErMiao San Inhibits Angiogenesis in Rheumatoid Arthritis by Suppressing JAKSTAT Signaling Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156138
Modern Language Association (MLA)
He, Lianhua…[et al.]. ErMiao San Inhibits Angiogenesis in Rheumatoid Arthritis by Suppressing JAKSTAT Signaling Pathways. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1156138
American Medical Association (AMA)
He, Lianhua& Qin, Qingxia& He, Juan& Wang, Han& Hu, Yiping& He, Wencheng…[et al.]. ErMiao San Inhibits Angiogenesis in Rheumatoid Arthritis by Suppressing JAKSTAT Signaling Pathways. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1156138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156138