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Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus
Joint Authors
Sulaiman, Siti Amrah
Mohd Sairazi, Nur Shafika
Asari, Mohd Asnizam
Muzaimi, Mustapha
Mummedy, Swamy
Sirajudeen, Kuttulebbai N. S.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The protective effect of tualang honey (TH) on neuroinflammation and caspase-3 activity in rat cerebral cortex, cerebellum, and brainstem after kainic acid- (KA-) induced status epilepticus was investigated.
Male Sprague-Dawley rats were pretreated orally with TH (1.0 g/kg body weight) five times at 12 h intervals.
KA (15 mg/kg body weight) was injected subcutaneously 30 min after last oral treatment.
Rats were sacrificed at 2 h, 24 h, and 48 h after KA administration.
Neuroinflammation markers and caspase-3 activity were analyzed in different brain regions 2 h, 24 h, and 48 h after KA administration.
Administration of KA induced epileptic seizures.
KA caused significant (p < 0.05) increase in the level of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), glial fibrillary acidic protein (GFAP), allograft inflammatory factor 1 (AIF-1), and cyclooxygenase-2 (COX-2) and increase in the caspase-3 activity in the rat cerebral cortex, cerebellum, and brainstem at multiple time points.
Pretreatment with TH significantly (p < 0.05) reduced the elevation of TNF-α, IL-1β, GFAP, AIF-1, and COX-2 level in those brain regions at multiple time points and attenuated the increased caspase-3 activity in the cerebral cortex.
In conclusion, TH reduced neuroinflammation and caspase-3 activity after kainic acid- (KA-) induced status epilepticus.
American Psychological Association (APA)
Mohd Sairazi, Nur Shafika& Sirajudeen, Kuttulebbai N. S.& Muzaimi, Mustapha& Mummedy, Swamy& Asari, Mohd Asnizam& Sulaiman, Siti Amrah. 2018. Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1156144
Modern Language Association (MLA)
Mohd Sairazi, Nur Shafika…[et al.]. Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1156144
American Medical Association (AMA)
Mohd Sairazi, Nur Shafika& Sirajudeen, Kuttulebbai N. S.& Muzaimi, Mustapha& Mummedy, Swamy& Asari, Mohd Asnizam& Sulaiman, Siti Amrah. Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1156144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156144