The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3KAkt Pathway
Joint Authors
Tan, Lingjing
Mei, Zhigang
Huang, Weifeng
Feng, Zhitao
Ou, Bingjin
Tao, Wei
Yang, Songbai
Feng, Jiateng
Wang, Jinfeng
Yang, Tong
Wu, Hanyu
Huang, Yaguang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Geum japonicum Thunb.
var.
chinense (GJ) is a type of wild vegetable found in China and other Asian countries; it has been reported that its extracts possess a neuroprotective effect against cerebral ischemia reperfusion (CIR) injury.
The aim of this study is to explore the effect GJ extracts on transient focal CIR injury and neurons apoptosis and to clarify its possible underlying mechanisms in vivo.
Our results indicated that pretreatment with GJ extracts significantly ameliorated the infarct volume, decreased neurological deficits, lessened neural cells apoptosis, downregulated GFAP activity level, and increased surviving neurons.
Moreover, GJ extracts preadministration increased Bcl-2 levels and attenuated the increase in the expressions of Bax and it also lowered the cleaved caspase-3 activity in ischemic cortex tissues which was caused by CIR and increased the expression of PI3K and p-Akt.
The above effects of high dose of GJ (GJ-H) group were much better than those of low dose of GJ (GJ-L), which indicated that GJ extracts may be helpful in the suppression of CIR injury with a dose-dependent manner.
American Psychological Association (APA)
Ou, Bingjin& Tao, Wei& Yang, Songbai& Feng, Jiateng& Wang, Jinfeng& Yang, Tong…[et al.]. 2018. The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156148
Modern Language Association (MLA)
Ou, Bingjin…[et al.]. The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1156148
American Medical Association (AMA)
Ou, Bingjin& Tao, Wei& Yang, Songbai& Feng, Jiateng& Wang, Jinfeng& Yang, Tong…[et al.]. The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3KAkt Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156148