Effects of Modified Zhisou Powder on Airway Mucus Production in Chronic Obstructive Pulmonary Disease Model Rats with Cold-Dryness Syndrome
Joint Authors
Wang, Jing
Li, Feng-sen
Zhen, Gao
Jing, Jing
Dan, Xu
Zheng, Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
In China, the Chinese medicine formula modified zhisou powder (MZP) is commonly used to treat COPD with cold-dryness syndrome (CDSCOPD) to relieve cough and sputum.
However, the underlying mechanisms of MZP on treating CDSCOPD remain to be elucidated.
Methods.
COPD and CDSCOPD rat models were established; MZP was given to CDSCOPD rats in the last 7 days of the 97-day model establishment.
Then the rats were subjected to lung function measurement.
Pathological changes in lungs were observed through paraffin section and H&E staining.
The mRNA and protein levels of AQP1, 4, and 5 and Muc5AC and Muc5B in lung were determined by quantitative RT-PCR and western blotting.
NE levels was determined by ELISA.
Results.
The impaired lung functions were observed in rats exposed to cigarette smoke.
Among all parameters evaluating lung functions, only tidal volume demonstrates a further decrease in CDSCOPD when compared with COPD, indicating further impaired pulmonary ventilation functions upon cold-dryness stimulation.
The intervention of MZP effectively improved lung functions parameters, prevented the inflammations, and eliminated the increases of AQP4 and 5 and the decrease of Muc5AC in lung.
Conclusion.
MZP probably improves pulmonary functions in CDSCOPD through inhibiting lung inflammation, increasing expressions of AQPs, and decreasing Muc5AC expression in lung.
American Psychological Association (APA)
Zhen, Gao& Wang, Jing& Jing, Jing& Dan, Xu& Zheng, Li& Li, Feng-sen. 2018. Effects of Modified Zhisou Powder on Airway Mucus Production in Chronic Obstructive Pulmonary Disease Model Rats with Cold-Dryness Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156152
Modern Language Association (MLA)
Zhen, Gao…[et al.]. Effects of Modified Zhisou Powder on Airway Mucus Production in Chronic Obstructive Pulmonary Disease Model Rats with Cold-Dryness Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156152
American Medical Association (AMA)
Zhen, Gao& Wang, Jing& Jing, Jing& Dan, Xu& Zheng, Li& Li, Feng-sen. Effects of Modified Zhisou Powder on Airway Mucus Production in Chronic Obstructive Pulmonary Disease Model Rats with Cold-Dryness Syndrome. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156152