The Chinese Herb Yi-Qi-Huo-Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy
Joint Authors
Wang, Xiangsheng
Huang, Jing
Wang, Shengyi
Ni, Qing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
To study the effect of the Chinese herb Yi-qi-huo-xue on cardiomyopathy in diabetic rats.
Methods.
Rats were fed a high fat and high glucose diet and injected with 50 ml/kg streptozotocin (STZ) to induce diabetic cardiomyopathy (DCM), followed by treatment with Yi-qi-huo-xue for 4 weeks.
We measured the rats’ heart weight index, observed the myocardial morphology using hematoxylin eosin (HE) staining, and determined the content of collagen types I and III in the myocardium using enzyme-linked immunosorbent assay (ELISA).
We determined Bcl-2, Bax, and P53 protein expression by Western blot analysis and the cardiomyocyte apoptosis rate via a flow cytometry assay.
Results.
Compared with the rats in the control group, the diabetic rats gained weight and had increased blood sugar levels, an enhanced heart weight index, and increased myocardial pathophysiological damage.
There was a decrease in their Bcl-2 expression, and their Bax and P53 expression increased.
The Bcl-2/Bax ratio was enhanced, and there was an increase in the content of collagen types I and III in the myocardium.
After treatment with Yi-qi-huo-xue, all levels listed above returned to normal.
Conclusion.
The Chinese herb Yi-qi-huo-xue degraded the myocardial interstitial collagen types I and III to protect the myocardium of the diabetic rats, thus delaying the role of myocardial fibrosis.
Yi-qi-huo-xue could play an important role in protecting the myocardium of DCM rats by enhancing the expression of the Bcl-2 protein, inhibiting the expression of the Bax and P53 proteins, increasing the ratio of Bcl-2/Bax, and inhibiting the apoptosis of cardiomyocytes.
American Psychological Association (APA)
Wang, Xiangsheng& Huang, Jing& Wang, Shengyi& Ni, Qing. 2018. The Chinese Herb Yi-Qi-Huo-Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156162
Modern Language Association (MLA)
Wang, Xiangsheng…[et al.]. The Chinese Herb Yi-Qi-Huo-Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156162
American Medical Association (AMA)
Wang, Xiangsheng& Huang, Jing& Wang, Shengyi& Ni, Qing. The Chinese Herb Yi-Qi-Huo-Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156162