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Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections
Joint Authors
Lee, Dong-Soo
Ahn, Hyo Jun
Kim, Dong Pil
Chu, Myeong Su
Yun, Hyeon Jeong
Kim, Seok-Hwan
Lee, Seung Woo
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aims.
To establish the efficacy and safety of ilaprazole, levofloxacin, and amoxicillin as a first-line eradication treatment for Helicobacter pylori.
Methods.
Patients with gastric ulcer, duodenal ulcer, or gastritis, as detected by esophagogastroduodenoscopy with confirmed H.
pylori infection between September 2014 and November 2015, were enrolled in the study.
All participants received ilaprazole (10 mg bid), levofloxacin (500 mg bid), and amoxicillin (1000 mg bid) for 10 days.
H.
pylori eradication was confirmed by a 13C-urea breath test at 6–8 weeks after the end of treatment.
Results.
Of 84 patients included in the analysis, the eradication rate was 88.8% in the per protocol group (n=80).
Demographic factors such as age, gender, body mass index (BMI), alcohol, smoking, hypertension, diabetes mellitus, and peptic ulcer did not affect the eradication rate.
However, multivariate analysis showed that overweight patients and patients with cerebrovascular accident (CVA) had a significantly lower eradication rate than patients with normal BMI and without CVA.
Laboratory test results did not change significantly after treatment.
A total of six (7.5%) patients developed eight adverse reactions.
Conclusions.
A 10-day triple therapy containing ilaprazole, levofloxacin, and amoxicillin is a safe alternative first-line eradication treatment for H.
pylori.
American Psychological Association (APA)
Ahn, Hyo Jun& Kim, Dong Pil& Chu, Myeong Su& Yun, Hyeon Jeong& Kim, Seok-Hwan& Lee, Seung Woo…[et al.]. 2017. Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156165
Modern Language Association (MLA)
Ahn, Hyo Jun…[et al.]. Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections. Gastroenterology Research and Practice No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1156165
American Medical Association (AMA)
Ahn, Hyo Jun& Kim, Dong Pil& Chu, Myeong Su& Yun, Hyeon Jeong& Kim, Seok-Hwan& Lee, Seung Woo…[et al.]. Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156165