Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis
Joint Authors
Zhang, Xinwen
Deng, Chunfu
Zhao, Baohong
Hu, Yue
Wang, Biyao
Yan, Xu
Yu, Tianhao
Wang, Sijian
Nakanishi, Hiroshi
Wu, Zhou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Periodontitis is an infectious disease whereby the chronic inflammatory process of the periodontium stimulated by bacterial products induces specific host cell responses.
The activation of the host cell immune system upregulates the production of inflammatory mediators, comprising cytokines and proteolytic enzymes, which contribute to inflammation and bone destruction.
It has been well known that periodontitis is related to systemic inflammation which links to numerous systemic diseases, including diabetes and arteriosclerosis.
Furthermore, periodontitis has been reported in association with neurodegenerative diseases such as Alzheimer’s disease (AD) in the brain.
Regarding immune responses and inflammation, cathepsin B (CatB) plays pivotal role for the induction of IL-1β, cathepsin K- (CatK-) dependent active toll-like receptor 9 (TLR9) signaling, and cathepsin S (CatS) which involves in regulating both TLR signaling and maturation of the MHC class II complex.
Notably, both the production and proteolytic activities of cathepsins are upregulated in chronic inflammatory diseases, including periodontitis.
In the present review, we focus on the roles of cathepsins in the innate and adaptive immune responses within periodontitis.
We believe that understanding the roles of cathepsins in the immune responses in periodontitis would help to elucidate the therapeutic strategies of periodontitis, thus benefit for reduction of systemic diseases as well as neurodegenerative diseases in the global aging society.
American Psychological Association (APA)
Yan, Xu& Wu, Zhou& Wang, Biyao& Yu, Tianhao& Hu, Yue& Wang, Sijian…[et al.]. 2020. Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156171
Modern Language Association (MLA)
Yan, Xu…[et al.]. Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1156171
American Medical Association (AMA)
Yan, Xu& Wu, Zhou& Wang, Biyao& Yu, Tianhao& Hu, Yue& Wang, Sijian…[et al.]. Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1156171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156171