Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
Joint Authors
Xiang, Jin
Zhao, Jianlei
Xiong, Wenbi
Liu, Litao
Tang, Mei
Yuan, Zhu
Li, George Q.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Da-Cheng-Qi-Decoction (DCQD) has been used in the treatment of acute pancreatitis (AP) in China for many years.
The aim of the current study was to examine the principal ingredient rhubarb of DCQD and its potential link to the pancreatic repair effects in rats with AP.
The pancreatitis was induced in SD rats by intraperitoneal injections of cerulein.
The results showed that rhubarb significantly increased blood perfusion of pancreatic tissue, reversed mitochondrial damage, and promoted pancreatic acinar and stellate cell proliferation.
In addition, the rhein (from rhubarb) had high distribution in pancreas tissue and protected mitochondria in AR42J cells via the activation of PI3K/AKT/mTOR signaling pathway and activity inhibition of AMPK (P < 0.05).
The results provide some preclinical evidence on the protective effects of DCQD for the treatment of acute pancreatitis.
Rhein is regarded to be the active compound of rhubarb and can be expected to be a new compound for the treatment of AP.
American Psychological Association (APA)
Zhao, Jianlei& Li, George Q.& Xiong, Wenbi& Liu, Litao& Xiang, Jin& Tang, Mei…[et al.]. 2018. Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156175
Modern Language Association (MLA)
Zhao, Jianlei…[et al.]. Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156175
American Medical Association (AMA)
Zhao, Jianlei& Li, George Q.& Xiong, Wenbi& Liu, Litao& Xiang, Jin& Tang, Mei…[et al.]. Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156175