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Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer
Joint Authors
Liu, Lu-Ming
Chen, Lian-Yu
Cheng, Chien-shan
Qu, Chao
Meng, Zhi-qiang
Wang, Peng
Gao, HuiFeng
Zhan, Ling
Wang, FengJiao
Li, Ye
Chen, Hao
Chen, HaiFeng
Chen, Zhen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Methyl protodioscin (MPD) is one of the main bioactive components in the plant of Dioscoreaceae.
MPD has been demonstrated to possess antitumor activities.
However, its role in pancreatic cancer and the underlying molecular mechanisms are poorly defined.
In the present study, we demonstrated that MPD inhibited proliferation and promoted apoptosis of pancreatic cancer.
Furthermore, our results demonstrated that MPD decreased oncogene c-Myc in protein level and resulted in concomitant reduction in glycolysis.
In vivo assays with xenograft mouse model further confirmed the in vitro observations, which indicated that MPD inhibited 18FDG uptake in tumors formed by subcutaneously injection of MIA PaCa-2 cells.
Collectively, our present study uncovered novel antitumor functions of MPD in pancreatic cancer and provided the possible molecular mechanism.
American Psychological Association (APA)
Chen, Lian-Yu& Cheng, Chien-shan& Gao, HuiFeng& Zhan, Ling& Wang, FengJiao& Qu, Chao…[et al.]. 2018. Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156183
Modern Language Association (MLA)
Chen, Lian-Yu…[et al.]. Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156183
American Medical Association (AMA)
Chen, Lian-Yu& Cheng, Chien-shan& Gao, HuiFeng& Zhan, Ling& Wang, FengJiao& Qu, Chao…[et al.]. Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156183