Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase
Joint Authors
Yuk, Taewon
Kim, Younghwa
Yang, Jinwoo
Sung, Jeehye
Lee, Junsoo
Jeong, Heon Sang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We aimed to investigate the effects of nobiletin on hepatic lipogenesis in high glucose-induced lipid accumulation in HepG2 cells.
Nobiletin, a citrus polymethoxyflavonoid with six methoxy groups, is present abundantly in the peels of citrus fruits.
HepG2 cells were incubated in Dulbecco’s modified Eagle’s medium containing high glucose (25 mM) and subsequently treated with nobiletin at different concentrations (5, 25, and 50 μM).
Results showed that nobiletin markedly inhibited high glucose-induced hepatic lipid accumulation in HepG2 cells.
In addition, it reduced the protein expression of lipogenic factors, including sterol regulatory element-binding protein 1c (SREBP-1c) and fatty acid synthase (FAS).
Nobiletin significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase.
Pretreatment with compound C, an AMPK inhibitor, abolished the inhibitory effects of nobiletin on SREBP-1c and FAS expression.
These results suggested that nobiletin might attenuate high glucose-induced lipid accumulation in HepG2 hepatocytes via modulation of AMPK signaling pathway.
Therefore, nobiletin might be useful for the prevention and treatment of nonalcoholic fatty liver diseases.
American Psychological Association (APA)
Yuk, Taewon& Kim, Younghwa& Yang, Jinwoo& Sung, Jeehye& Jeong, Heon Sang& Lee, Junsoo. 2018. Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156207
Modern Language Association (MLA)
Yuk, Taewon…[et al.]. Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156207
American Medical Association (AMA)
Yuk, Taewon& Kim, Younghwa& Yang, Jinwoo& Sung, Jeehye& Jeong, Heon Sang& Lee, Junsoo. Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156207