Efficacy of Curcumin with Iontophoretic Application on Paw Edema and Hematological Responses in Collagen-Induced Arthritis Rat Models
Joint Authors
Alghadir, Ahmad
Miraj, Mohammad
Ali, Sharique
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
According to previous studies, oral administration of curcumin elucidates anti-inflammatory effect irrespective of its poor bioavailability.
This study aims to measure the efficacy of lyophilized curcumin extracts with iontophoresis in arthritic rat models.
Methods.
Lyophilization and characterization of curcumin using the standard HPTLC method was carried out followed by induction of inflammatory arthritis in male albino rats.
The animals were then treated with curcumin in three different forms, i.e., oral curcumin (OCU), oral curcumin with topical application (OCU + TOCU), and oral curcumin along with iontophoretically applied curcumin (OCU + IOCU).
Various objective variables including body weight, paw edema, arthritic scores, and hematological and biochemical parameters, as well as histopathological examinations were conducted.
Results.
All the curcumin-treated groups showed significant alleviation of arthritic condition (p∗<0.05) when compared with arthritic controls.
Group V (OCU + IOCU) demonstrated maximum therapeutic effect by restoring the body weight, decreasing the paw edema, and normalizing the Erythrocyte sedimentation rate and leukocyte count, when compared with other experimental rat groups (p∗∗<0.01).
Conclusions.
Iontophoretic administration of curcumin may ameliorate arthritic symptoms significantly, and the effect is assumed to be due to better penetration and enhanced bioavailability.
Geriatrics patients are supposed to be benefited fairly by this technique.
American Psychological Association (APA)
Alghadir, Ahmad& Miraj, Mohammad& Ali, Sharique. 2020. Efficacy of Curcumin with Iontophoretic Application on Paw Edema and Hematological Responses in Collagen-Induced Arthritis Rat Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156215
Modern Language Association (MLA)
Alghadir, Ahmad…[et al.]. Efficacy of Curcumin with Iontophoretic Application on Paw Edema and Hematological Responses in Collagen-Induced Arthritis Rat Models. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1156215
American Medical Association (AMA)
Alghadir, Ahmad& Miraj, Mohammad& Ali, Sharique. Efficacy of Curcumin with Iontophoretic Application on Paw Edema and Hematological Responses in Collagen-Induced Arthritis Rat Models. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156215