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Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during the Natural History of Chronic Hepatitis B Virus Infection
Joint Authors
Wu, Wei-kang
Xie, He-Ping
Liu, Zhi-Ping
Zhang, Jiong-Shan
Dai, Min
Xiao, Ge-Min
Yang, Hong-Zhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study is to investigate traditional Chinese medicine syndrome (TCMS) patterns and their association with hepatitis B surface antigen (HBsAg) levels during the natural history of chronic hepatitis B virus infection (CHB).
Patients were categorized according to the phase of CHB, as follows: immune tolerance (ITP); immune clearance (ICP); low or nonreplication (LRP); reactivation (RAP); hepatic cirrhosis (HC); and primary liver cancer (PLC).
TCMS patterns were classified among the following types: spleen-kidney deficiency (SKD); liver-qi depression (LQD); damp-heat in liver-gallbladder (LGDH); liver-kidney deficiency (LKD); and blood stasis blocking collateral (BSBC).
HBsAg levels and other serological indicators were quantified for all patients and their association with TCMS was statistically analyzed and determined.
Two hundred and eighty-nine patients with CHB were included.
During the natural history of CHB, TCMS patterns were statistically different among the different phases (P < 0.001).
The most frequently occurring syndromes among the six progressive phases were SKD, LGDH, LKD, LGDH, BSBC, and LGDH, respectively.
The predominant patterns in the inactive stage (ITP + LRP), active stage (ICP + RAP), and late or advanced stage (HC + PLC) were SKD (31%), LGDH (51.8%) and BSBC (34.4%), respectively.
Median HBsAg levels were also statistically different among the five patterns of TCMS (P < 0.001).
The highest HBsAg levels were observed in SKD (4.48 log10 IU/mL).
Medium levels were in LQD (3.91 log10 IU/mL) and LGDH (3.90 log10 IU/mL).
The lowest HBsAg levels were in LKD (3.60 log10 IU/mL) and the second lowest levels in BSBC (3.81 log10 IU/mL).
In addition, HBsAg levels in LKD and BSBC were significantly lower than those in SKD, LQD, and LGDH (P < 0.05 or 0.001).
TCMS was altered during the natural history of CHB and correlated with HBsAg titers.
This study could provide further insight into the therapy of CHB.
American Psychological Association (APA)
Xie, He-Ping& Liu, Zhi-Ping& Zhang, Jiong-Shan& Dai, Min& Xiao, Ge-Min& Wu, Wei-kang…[et al.]. 2018. Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during the Natural History of Chronic Hepatitis B Virus Infection. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156224
Modern Language Association (MLA)
Xie, He-Ping…[et al.]. Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during the Natural History of Chronic Hepatitis B Virus Infection. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156224
American Medical Association (AMA)
Xie, He-Ping& Liu, Zhi-Ping& Zhang, Jiong-Shan& Dai, Min& Xiao, Ge-Min& Wu, Wei-kang…[et al.]. Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during the Natural History of Chronic Hepatitis B Virus Infection. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156224